Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-176-9 | CAS number: 104-12-1
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: results sufficiently stated
Data source
Reference
- Reference Type:
- publication
- Title:
- Maximum permissible concentration of p-chlorophenyl isocyanate in factory air
- Author:
- Frolova IN
- Year:
- 1 966
- Bibliographic source:
- Hygiene & Sanitation 31 (7-9), 481-483 (Engl. translation)
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- eye irritation
- Principles of method if other than guideline:
- threshold of irritating effects on eyes (no further data) was determined
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorophenyl isocyanate
- EC Number:
- 203-176-9
- EC Name:
- 4-chlorophenyl isocyanate
- Cas Number:
- 104-12-1
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-4-isocyanatobenzene
- Details on test material:
- TS-Freetext:
4-Chlorophenyl isocyanate, no purity specified
Constituent 1
Method
- Subjects:
- human volunteers (no further data)
- Route of exposure:
- ocular
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- subjects complained of unpleasant sensations in their eyes
Any other information on results incl. tables
RM-Freetext:
In the case of human subjects the threshold of irritating
action was 0.0008 mg/l for a one-minute exposure (no further
information from the English translation of the Russian
publication)
Applicant's summary and conclusion
- Executive summary:
In the case of human subjects the threshold of irritating action was 0.0008 mg/l for a one-minute exposure.
The subjects complained of unpleasant sensations in their eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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