Quaternary ammonium compounds, bis(C16-18 and C18-unsatd. alkyl)dimethyl, chlorides

Toxicity to terrestrial plants

Administrative data

Endpoint:

toxicity to terrestrial plants: long-term

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

review article or handbook

Title:

Effect on the growth of Sorghum bicolor, Helianthus annuus and Phaseolus aureus, BIOD 82/06

Author:

A. J. Windeatt

Year:

1987

Bibliographic source:

ECETOC Technical Report No. 53, DHTDMAC Aquatic & terrestrial Hazard Assessment

Materials and methods

Principles of method if other than guideline:

no details on guideline given

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides

EC Number:

263-090-2

EC Name:

Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides

Cas Number:

61789-80-8

Molecular formula:

R2Me2N(+)Cl(-) whereas R = mainly C16, 18-alkyl molecular weight range is based on R=14 (lower limit value) and R=18 (higher limit value)

IUPAC Name:

N,N-Dimethyl-N,N-di-n-alkyl(C16-18)-ammoniumchloride

Details on test material:

The test material had a a.i. content of 76.1%.

Study design

Test type:

seedling emergence toxicity test

Study type:

laboratory study

Results and discussion

Effect concentrations

Effect concentrations 1

Species:

Sorghum bicolor

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

seedling emergence

Effect concentrations 2

Species:

Sorghum bicolor

Duration:

28 d

Dose descriptor:

EC50

Effect conc.:

2 530 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

seedling emergence

Effect concentrations 3

Species:

Helianthus annuus

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

seedling emergence

Effect concentrations 4

Species:

Helianthus annuus

Duration:

28 d

Dose descriptor:

EC50

Effect conc.:

2 930 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

seedling emergence

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Remarks:

based on assessment within EU RAR on DODMAC (2009)

Conclusions:

Windeatt has tested DHTDMAC (76.1% a.i.) in a 28d seedling emergence test with two plant species (Sorghum bicolor & Helianthus annuus). The NOEC 28d was 1000 mg/kg dw. for Sorghum bicolor as well as Helianthus annuus, the EC50 28d was 2530 mg/kg dw respectively 2930 mg/kg dw. This chronic plant test demonstrates the low plant toxicity of DHTDMAC.