Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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First-aid measures

The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Description of first aid measures

General advice:
First Aid responders should pay attention to self-protection and use the recommended protective clothing
Take off contaminated clothing and shoes immediately.
Move out of dangerous area.
Keep warm and in a quiet place.

If inhaled:
Provide fresh air.
If not breathing, give artificial respiration.
Keep the victim calm and in a semi-upright position.
Call a physician immediately.

In case of skin contact:
Wash off immediately with plenty of water for at least 15 minutes.
Call a physician immediately.

In case of eye contact:
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Call a physician immediately.

If swallowed:
Clean mouth with water and drink afterwards plenty of water.
Never give anything by mouth to an unconscious person.
Do NOT induce vomiting.
Call a physician immediately.

Fire-fighting measures

The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).
Extinguishing media

Suitable extinguishing media:
Dry extinguishing media based on NaCl (e.g.Totalit M) or pulverized limestone.

Unsuitable extinguishing media:
Water
Carbon dioxide (CO2)
Foam

Special hazards arising from the substance or mixture
Specific hazards during firefighting:
May form toxic gases on heating or in case of fire.
Vapours may form explosive mixture with air.
Vapours are heavier than air and may spread along floors.
Flash back possible over considerable distance.

Advice for firefighters
Special protective equipment for firefighters:
Wear full protective clothing and self-contained breathing apparatus.

Further information:
Use water spray to cool unopened containers.
Be aware of a dangerous reaction with water, if the container is ruptured.
Collect contaminated fire extinguishing water separately. This must not be discharged into drains.
Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations.

Accidental release measures

The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Personal precautions, protective equipment and emergency procedures

Personal precautions:
Remove all sources of ignition.
Ensure adequate ventilation.
Wear personal protective equipment.
Avoid contact with skin, eyes and clothing.
Do not breathe gas/fumes/vapour/spray.
Keep people away from and upwind of spill/leak.

Environmental precautions
Environmental precautions:
Do not flush into surface water or sanitary sewer system.
Avoid subsoil penetration.

Methods and materials for containment and cleaning up
Methods for cleaning up:
Never allow contact with water.
Cover spilled material with limestone powder.
Pick up and transfer to properly labelled containers.
Adequate disposal

Handling and storage

The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).
Precautions for safe handling

Advice on safe handling:
Handle under inert gas.
Provide sufficient air exchange and/or exhaust in work rooms.
Provide exhaust ventilation close to floor level.
Never allow water to come into contact with the product.
Wear personal protective equipment.
Handle in accordance with good industrial hygiene and safety practice.

Advice on protection against fire and explosion:
Vapours may form explosive mixtures with air.
Vapours are heavier than air and may spread along floors.
Flash back possible over considerable distance.
Keep away from sources of ignition - No smoking.
Take precautionary measures against static discharges.
Use explosion-proof equipment.
Uncleaned empty containers can contain product gases, which form explosive mixtures with air.

Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containers:
Keep under inert gas.
Keep containers tightly closed in a dry, cool and well-ventilated place.
Keep away from heat.
Protect from direct sunlight.
Protect from moisture.
Protect from frost.
Avoid contact with air/oxygen.

Advice on common storage:
Incompatible with oxidizing agents.
Do not store near acids.
Alcohols
Never allow product to get in contact with water during stor-age.

Specific end use(s)

Specific use(s):
Reagent for organic synthesis.

Transport information

Land transport (ADR/RID)

UN number:
The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

3399
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE Ethylmagnesium bromide, Diethyl ether
Class:
4.3
Classification code:
WF1
Packaging group:
I
Labels:
4.3 (3)
SpecialProvisionsopen allclose all
Shippingopen allclose all
Remarksopen allclose all

Marine transport (IMDG)

UN number:
The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

3399
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE Ethylmagnesium bromide, Diethyl ether
Class:
4.3
Packaging group:
I
EmS code:
EmS Number 1
:
F-G
EmS Number 2
:
S-N
Labels:
4.3 (3)
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).
3399
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE Ethylmagnesium bromide, Diethyl ether
Class:
4.3
Packaging group:
I
Labels:
4.3 (3)
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Engineering measures
Provide sufficient air exchange and/or exhaust in work rooms.
Provide exhaust ventilation close to floor level.
Take precautionary measures against static discharges.
Electrical equipment should be protected to the appropriate standard.
Personal protective equipment

Respiratory protection:
In case of insufficient ventilation wear suitable respiratory equipment.
For short-time or low exposures, use breathing apparatus with a filter.
Recommended Filter type:
A-P2
For intensive or prolonged exposure, use a self-contained breathing apparatus.

Hand protection:
Glove material: Flame retardant gloves
Protective gloves complying with EN 374.
The choice of an appropriate glove does not only depend on its material but also on other quality features and is different from one producer to the other.
The exact break through time can be obtained from the protective glove producer and this has to be observed.
Protective gloves have to be replaced at the first sign of deterioration.

Eye protection:
Eye protection (EN 166)
Tightly fitting safety goggles

Skin and body protection:
Flame retardant, antistatic and chemical resistant protective clothing

Hygiene measures:
Take off contaminated clothing and shoes immediately.
Avoid contact with skin, eyes and clothing.
Do not breathe gas/fumes/vapour/spray.
Keep away from food, drink and animal feedingstuffs.
Smoking, eating and drinking should be prohibited in the
application area.
Wash hands before breaks and at the end of workday.

Protective measures:
Facilities storing or utilizing this material should be equipped with an eyewash facility and safety shower.
Handle in accordance with good industrial hygiene and safety practice.

Control parameters:

Diethyl ether: TWA (2000/39/EC, 2000-06-16): 100 ppm; 308 mg/m3
Diethyl ether: STEL (2000/39/EC, 2000-06-16): 200ppm; 616 mg/m3

Stability and reactivity

The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Reactivity

Risk of violent reaction.

Chemical stability

Decomposes on heating., Sensitive to air., Decomposition under influence of moisture is highly ac-celerated by heating.

Possibility of hazardous reactions

Hazardous reactions:
Reacts violently with water.
May form explosive peroxides.
Vapours may form explosive mixture with air.

Conditions to avoid

Conditions to avoid:
Keep away from open flames, hot surfaces and sources of ignition.
Protect from frost, heat and sunlight.
Protect from moisture.
Avoid formation of aerosol.
Static discharge.
Avoid contact with air/oxygen.

Incompatible materials
Materials to avoid:

Water Acids
Alcohols Oxidizing agents Other protic substances.

Hazardous decomposition products

The following information applies to the substance in organic solution (see IUCLID 3.4: Information on mixtures).

Risk of decomposition:
Decomposes in contact with water.
Ethane

Thermal decomposition:
To avoid thermal decomposition, do not overheat.

Disposal considerations

The following information applies to the substance in diethyl ether (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Waste treatment methods

Product:
Dispose of in accordance with local regulations.

Contaminated packaging:
Refer to manufacturer/supplier for information on recovery/recycling.

Waste Code:
Waste codes should be assigned by the user, preferably in discussion with the waste disposal authorities.