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EC number: 201-940-6 | CAS number: 89-79-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication with limited documentation, limited set of parameters assessed
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effect of essential oils on the concentration of serum lipids and apolipoproteins in rats.
- Author:
- Imaizumi K et al.
- Year:
- 1 985
- Bibliographic source:
- Agric. Biol. Chem.; 49 (9), 2795-6
- Reference Type:
- secondary source
- Title:
- Effect of essential oils on the concentration of serum lipids and apolipoproteins in rats.
- Author:
- Imaizumi K et al
- Year:
- 1 985
- Bibliographic source:
- Cited in: WHO (2001). Pulegone and related substances. WHO Food Additives Series 46: 221-243.
- Reference Type:
- secondary source
- Title:
- Effect of essential oils on the concentration of serum lipids and apolipoproteins in rats.
- Author:
- Imaizumi K et al
- Year:
- 1 985
- Bibliographic source:
- Cited in: Bhatia et al. 2008; Fragrance material review on isopulegol; Food. Chem. Toxicol. 46; 185-189; Cited in RIFM/FEMA database (Location 3215)
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Isopulegol
- EC Number:
- 201-940-6
- EC Name:
- Isopulegol
- Cas Number:
- 89-79-2
- Molecular formula:
- C10H18O
- IUPAC Name:
- isopulegol
- Details on test material:
- Isopulegol; no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 248 +/- 4.1 g
- Diet: ad libitum
- Water: ad libitum
no further data
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
no further data
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- continuously in the diet
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5, 1% in the diet
Basis:
nominal in diet
- No. of animals per sex per dose:
- 3-4 males per group
- Control animals:
- yes, plain diet
- Details on study design:
- Rats were fasted overnight prior to blood sampling from abdominal aorta.
No further data - Positive control:
- Not applicable
Examinations
- Observations and examinations performed and frequency:
- Observations included body weight, liver weight and serum cholesterol, triacylglycerol and Apo A-1 levels.
- Sacrifice and pathology:
- No data
- Other examinations:
- No data
- Statistics:
- Student´s t test (no further data)
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Dose group 1%:
The relative weight of the liver and concentrations of cholesterol, Apo A-1 and triglyceride were significantly increased.
Body weight gain was slightly (non-significant) decreased. Food intake was unaffected.
Body weight change (g/14 days): 56 +/-3 (vs. 68 +/-8 in controls)
Liver weight (g/100g bw): 3.7 +/-0.1 (vs 3.3 +/-0.1 in controls)
Cholesterol (mg/dl): 135 +/-5 (vs 91 +/-1 in controls)
Triacylglycerol (mg/dl): 135 +/-9 (vs 98 +/-7 in controls)
Apo A-1 (mg/dl): 86 +/-5 (vs 66 +/-4 in controls)
Dose group 0.5%:
No details given.
In the review of the WHO Food Additives Series, a NOEL of 250 mg/kg bw/d (referring to the 0.5% dose group) has been set for this study.
Applicant's summary and conclusion
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