Registration Dossier
Registration Dossier
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EC number: 613-175-9 | CAS number: 6318-09-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18.11.1997 - 8.1.1998
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2,4,6-tris(propan-2-yl)benzene-1,3-diamine
- Cas Number:
- 6318-09-8
- Molecular formula:
- C12H26N2
- IUPAC Name:
- 2,4,6-tris(propan-2-yl)benzene-1,3-diamine
- Details on test material:
- yellowish powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: oil
- Details on oral exposure:
- 5%, 10%, 15% and 20% oil suspension
- Doses:
- 500 mg/kg
1000 mg/kg
1500 mg/kg
2000 mg/kg - No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 950 - < 1 400 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 130 - < 1 520 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 090 - < 1 390 mg/kg bw
- Mortality:
- 500 mg/kg 0%
1000 mg/kg 30 %
1500 mg/kg 60%
2000 mg/kg 100% - Clinical signs:
- other: Clinical signs 30 minutes after aplication. 500 - 2000 mg/kg: Congestion of lungs. Dilatation of stomach. 500 mg/kg: no signs
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Acute tox. 4 Criteria used for interpretation of results: OECD GHS
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