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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study conducted similar to OECD 425 with the following restrictions: One animal per dose and dosing was not staggered by 48 hours, study predates GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Test guideline
Qualifier:
no guideline followed
Guideline:
OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
Deviations:
yes
Remarks:
One animal per dose and dosing was not staggered by 48 hours, study predates GLP.
GLP compliance:
not specified
Remarks:
Study predates GLP
Test type:
other:
Limit test:
no

Test material

Constituent 1
Reference substance name:
Tetrrahydro-3-methylfuran
IUPAC Name:
Tetrrahydro-3-methylfuran
Constituent 2
Chemical structure
Reference substance name:
Tetrahydro-3-methylfuran
EC Number:
236-537-4
EC Name:
Tetrahydro-3-methylfuran
Cas Number:
13423-15-9
Molecular formula:
C5H10O
IUPAC Name:
tetrahydro-3-methylfuran

Test animals

Species:
rat
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source:no data
- Age at study initiation:adult
- Weight at study initiation:no data
- Fasting period before study:no data
- Housing:no data
- Diet (e.g. ad libitum):no data
- Water (e.g. ad libitum):no data
- Acclimation period:no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C):no data
- Humidity (%):no data
- Air changes (per hr):no data
- Photoperiod (hrs dark / hrs light):no data

IN-LIFE DATES: From: To:

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
3methyl tetrahydrofuran, as a suspension in corn oil, was administered by intragastric intubation to young adult rats as a single dose.
Doses:
670, 1000, 1500, 2250, 3400, 5000, 11000 mg/kg
No. of animals per sex per dose:
unknown
Control animals:
not specified
Details on study design:
survivors sacrificed 14 days after dosing

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: ALD
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Approximate lethal dose (ALD)
Mortality:
Rats adminstered 5,000 mg/kg bw and rats adminstered 11,000 mg/kg bw dead within 1 hour.
Clinical signs:
other: Lethal doses: Heavy breathing, prostration, body limp Nonlethal doses: prostration, disconfort, heavy breathing on day of dosing

Applicant's summary and conclusion

Conclusions:
Approximate Lethal Dose (ALD) = 5000 mg/kg bw
Executive summary:

3 -Methyltetrahydrofuran is slightly toxic when adminstered by intragastric intubation to young adult ChR-CD male rats in single doses; it Approximate Lethal Dose (ALD) is 5000 mg/kg of body weight.