Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
1.1 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
11 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.11 mg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
0.23 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
5.86 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.59 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.53 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Sufficient data are available for the derivation of PNEC values for tetrahydro-3-methylfuran (3-methyl-THF), including a 96-hr LC50 value in freshwater fish (Pimephales promelas) of 1100 mg/L from a non-GLP OECD 203 guideline study (DuPont, 1986) which served as the starting point. Other data considered for PNEC derivation included a 48-hr LC50 value in invertebrates (Daphnia magna) of 1742 mg/L from a non-GLP OECD 202 guideline study (DuPont 1980), an 8-day Toxicity Threshold Concentration (TTC) value (equivalent to EC3) in aquatic algae (Scenedesmus quadricauda) of 1850 mg/L from a non-GLP EC.3.-equivalent guideline study (Bringmann, 1976), and a 33-day NOEC value of 108 mg/L from a non-GLP / non-guideline study (Call, 1985), all of which were data obtained on the read-across substance (tetrahydrofuran) and to which a 2-fold safety factor was applied. Even with the 2-fold safety factor, the measured acute value on 3-methyl-THF, with an assessment factor of 1000, yielded the lowest and most reliable PNEC. An equivalent value would result by using the 33 -day NOEC of 108 mg/L from the long-term study on the read-across substance, which includes the 2-fold safety factor, and then applying an assessment factor of 100. From this single aquatic PNEC value, all other PNECs were derived according to the R.10 REACH Guidance either by applying the specified assessment factor or, in the case of sediments and soil, by applying the equilibrium partitioning coefficient method.

Conclusion on classification

Tetrahydro-3-methylfuran (3-methyl-THF) does not meet the criteria for classification as hazardous to the environment on the basis of a 96-hr LC50 value in freshwater fish (Pimephales promelas) of 1100 mg/L from a non-GLP OECD 203 guideline study (DuPont, 1986) and a PBT Assessment that concludes the substance is not PBT or vPvB.