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EC number: 700-308-1 | CAS number: 1335203-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to or similar to study guidelines (OECD406 and Method B6, 92/69/EEC Directive): GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- and Method B6 (92/69/EEC Directive)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- A mixture of isomers of branched tetracosane
- EC Number:
- 417-060-2
- EC Name:
- A mixture of isomers of branched tetracosane
- Cas Number:
- 151006-61-0
- Molecular formula:
- C24H50
- IUPAC Name:
- Hydrogenated dimerization products of 1-dodecene
- Reference substance name:
- 1-DODECENE DIMER, HYDROGENATED
- IUPAC Name:
- 1-DODECENE DIMER, HYDROGENATED
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- arachis oil
- Concentration / amount:
- Concentration of test material and vehicle used at each stage of induction
a) Intradermal induction 25% (w/v) in dried arachis oil BP
b) Topical induction undiluted liquid as supplied
Concentration of test material and vehicle used at each stage of challenge
a) Undiluted liquid as supplied
b) 75% (w/v) in dried arachis oil BP
Challengeopen allclose all
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- arachis oil
- Concentration / amount:
- Concentration of test material and vehicle used at each stage of induction
a) Intradermal induction 25% (w/v) in dried arachis oil BP
b) Topical induction undiluted liquid as supplied
Concentration of test material and vehicle used at each stage of challenge
a) Undiluted liquid as supplied
b) 75% (w/v) in dried arachis oil BP
- No. of animals per dose:
- 20 test animals and 10 control animals
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 75% w/v
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No skin reaction
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 75% w/v. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: No skin reaction .
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 75% (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No skin reaction
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 75% (w/v). No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: No skin reaction.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100% (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No skin reaction
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 100% (w/v). No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: No skin reaction.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100 % (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No skin reaction
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 100 % (w/v). No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: No skin reaction.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 75% (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No skin reaction
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 75% (w/v). No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No skin reaction.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 75% (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No skin reaction
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 75% (w/v). No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No skin reaction.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 100% (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No skin reaction
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 100% (w/v). No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No skin reaction.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 100% (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No skin reaction
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 100% (w/v). No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No skin reaction.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this study, the test material produced a 0% sensitization rate (0/20 animals) . The test material is not a skin sensitizer in the Magnusson & Kligman guinea pig maximization test. This finding does not warrant classification of the test material as a skin sensitizer under EU GHS guidelines and does not warrant classification under EU requirements for dangerous substances and preparations guidelines.
- Executive summary:
- A Magnusson-Kligman skin sensitization maximization test was carried out on 30 female albino Dunkin-Hartley guinea pigs (20 test and 10 control). The following concentrations of test material and vehicle were used at each stage of induction and at each stage of challenge: Intradermal induction - 25% w/v test material in dried arachis oil BP Topical induction - 100% test material (undiluted liquid as supplied) Topical challenge 75% w/v test material in dried arachis oil BP and 100% test material (undiluted liquid as supplied). On challenge, no skin reactions were noted at the application site in test group animals or in the control group at the 24 and 48 observations at either of the two concentrations. The test material produced a 0% sensitization rate in test (0/20) and control (0/10) animals. Hence, 1-dodecene dimer, hydrogenated is not a skin sensitizer in the Magnusson & Kligman guinea pig maximization test.
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