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Environmental fate & pathways

Adsorption / desorption

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Description of key information

A weight of evidence approach is being applied, as the Koc of the test item was being derived via the HPLC estimation method and from a QSPR computation. The result from the HPLC method is Koc < 18, which basically was being confirmed by the result from the QSPR computation Koc = 1.2. The substance therefore is to be considered as of very high mobility.

Key value for chemical safety assessment

Additional information

The HPLC method for Koc estimation is a guideline-conform study under GLP. However, the protocol as given by OECD Guideline 121 states "If the actual results show that the log Koc of the test substance is outside the calibration range the test should be repeated using different, more appropriate reference substances". As during this study the retention time of the test item was outside the retention times of the calibration substances (i.e. outside log Koc range 1.5 to 5.0), and the test still was not repeated, this has to be considered as some relvant deviation from the study protocol. Still, as stated in the study report, the chromatography of the test item resulted in one main peaks with well-defined and reproducible retention times, the HPLC method was therefore considered to be suitable for the purpose of the study. Furthermore in the study report QSPR computations of the estimated Koc of the test item are given, and these computed values are in alignment with the HPLC data.

Based on a weight of evidence approach the study result from the HPLC method Koc < 18 therefore can be condsidered as acceptable. Based on the mobility classification system of McCall (1981) the substance falls within the bracket Koc 0 - 50, and therefore is to be considered as of very high mobility.