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EC number: 200-876-6 | CAS number: 75-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 Oct 1980 - 23 Oct 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Nitromethane
- EC Number:
- 200-876-6
- EC Name:
- Nitromethane
- Cas Number:
- 75-52-5
- Molecular formula:
- CH3NO2
- IUPAC Name:
- nitromethane
- Details on test material:
- The test material contained 95.88% nitromethane, 3.31% nitroethane, 0.55% 2-nitropropane and 0.023% water by weight. Additional minor impurities were not identified.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Rabbits were at least 9 weeks of age and weighed 2 kg. Rabbits were individually caged during and after exposure. Rabbits were quarantined for at least 7 days. Animals were fed Purina Certified Rabbit Chow #5322 and water ad libitum. The diet was certified free of contaminants and the analysis was performed by the supplier. Every quarter the animals' drinking water was analyzed to ensure that the levels of contaminants were equal to or less than the recommended levels as per the Primary Drinking Water Regulations (40 CFR 141.11, 141.12, 141.14).
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4, 24 and 48 hours after application of the test material.
- Number of animals:
- 6
- Details on study design:
- To a hair free area on the back, the test material was applied under a 1 inch square gauze patch and then with an impervious rubberized cloth. The test material was applied to a single intact skin site per rabbit. The test material was left in contact with the skin for four hours. After exposure, the skin sites were wiped clean and left exposed to the air for the duration of the study. The treated skin site was visually examined for erythema, edema or any irreversible tissue destruction at 4, 24 and 48 hours after the inital application of the material. Skin reactions of erythema, edema or tissue destruction was noted and reported. Any tissue destruction was scored as a positive reaction (according to Draize, Association of Food and Drug Officials of the United States, p 48, 1959). Body weights were measured and recorded at 0 and 48 hours after exposure. Any animals which died during the test were necropsied and examined for tissues or organ damage. At 48 hours after the skin site examination, the animals were sacrificed by intravenous administration of benzyltrimethylammonium chloride.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4 hr
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4 hr
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not irritating at any time point
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Nitromethane was not irritating to the skin
- Other effects:
- Day 0 mean body weight was 2.789 +/- 0.127 kg while day 2 mean body weight was 2.826 +/- 0.118 kg.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Nitromethane was not irritating when applied to the skin.
- Executive summary:
The dermal irritation potential of nitromethane was examined with rabbits. Nitromethane was not irritating to the skin of rabbits.
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