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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on three hydrolysis studies as-
2., 3. and 4.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
yes
Remarks:
2. and 3. no data available, 4. yes
Duration:
5 d
Temp.:
50 °C
Initial conc. measured:
100 mg/L
Remarks:
2. Study was perforned at pH 4, 7 and 9, respectively.
pH:
7
Remarks:
3. Other details not known
Duration:
5 d
Temp.:
50 °C
Initial conc. measured:
20 mg/L
Remarks:
4. The study was performed at pH 4, 7 and 9, respectively.
Number of replicates:
2. Two Replicates
3. No data available
4. 2 replicates/pH solution
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Temp.:
50 °C
DT50:
> 5 d
Remarks on result:
other: 2. The test substance has no activity of hydrolysis and is stable at pH 4, pH 7 and pH 9.
pH:
7
DT50:
276 d
Remarks on result:
other: 3. Hydrolysis rate consrant of test chemical was determined to be 2.9 х 109 L/mol-sec
Temp.:
50 °C
Remarks on result:
other: 4. Although the half-life value of test chemical was not known, but at the preliminary test, the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water.
Details on results:
2. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days.
3. no data available
4. The residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days, at pH range 4, 7 & 9 and a temperature of 50°C or 276 days at pH 7.0, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C (ranges from 49-51°C) and pH of 4, 7 and 9, respectively. Initial test chemical concentration used for the study was 100 mg/l. Experiment was performed in 2 replicates.The test substance has no activity of hydrolysis and thus was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of50⁰C for 5 days. The half-life value of test chemical was determined to be > 5 daysat pH 4, 7 and 9, respectively & at a temperature of 50⁰C. Thus based on this, test chemical is considered to be not hydrolysable.

In an another study, the half-life and hydrolysis rate constant was determined of the test chemical. The hydrolysis rate constant of test chemical was determined to be 2.9 х 109 L/mol-sec with a corresponding half-lives of 276 days at pH 7, respectively. Based on the half-life value, it is concluded that the test chemical is not hydrolysable.

For the test chemical, the half-life of the test chemical was determined at different pH range.The preliminary study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Initial test chemical conc. Used for the study was 20 mg/l. Analytical method involve the use of HPLC. Although the half-life value of test chemical was not known, but at the preliminary test,the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50⁰C and at pH 4, 7 and 9, respectively. Based on this, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days, at pH range 4, 7 & 9 and a temperature of 50°C or 276 days at pH 7.0, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

 

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days, at pH range 4, 7 & 9 and a temperature of 50°C or 276 days at pH 7.0, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Key value for chemical safety assessment

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C (ranges from 49-51°C) and pH of 4, 7 and 9, respectively. Initial test chemical concentration used for the study was 100 mg/l. Experiment was performed in 2 replicates. The test substance has no activity of hydrolysis and thus was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of50⁰C for 5 days. The half-life value of test chemical was determined to be > 5 days at pH 4, 7 and 9, respectively & at a temperature of 50⁰C. Thus based on this, test chemical is considered to be not hydrolysable.

 

In an another study, the half-life and hydrolysis rate constant was determined of the test chemical. The hydrolysis rate constant of test chemical was determined to be 2.9 х 109 L/mol-sec with a corresponding half-lives of 276 days at pH 7, respectively. Based on the half-life value, it is concluded that the test chemical is not hydrolysable.

 

For the test chemical, the half-life of the test chemical was determined at different pH range. The preliminary study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Initial test chemical conc. Used for the study was 20 mg/l. Analytical method involve the use of HPLC. Although the half-life value of test chemical was not known, but at the preliminary test, the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50⁰C and at pH 4, 7 and 9, respectively. Based on this, it is concluded that the test chemical is not hydrolysable.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days, at pH range 4, 7 & 9 and a temperature of 50°C or 276 days at pH 7.0, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.