Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Written toxicokinetics assessment

Key value for chemical safety assessment

Additional information

It is not possible to evaluate the toxicokinetics of trimethylaluminium as the substance reacts with water to produce aluminium hydroxide and methane or methanol and reacts spontaneously in air to form aluminium oxide, carbon dioxide and water. Therefore, the toxicokinetics effects of aluminium oxide and aluminium hydroxide need to be considered when evaluating the effects of exposure to trimethylaluminium.

Absorption of aluminium by the oral, inhalation and dermal routes is predicted to be low. Filtration in the kidneys is the main route by which systemic aluminium is excreted.