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Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 Jul 2015 to 13 Jul 2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
no
Type of method:
other: Effusion method / Knudsen cell
Temp.:
20 °C
Vapour pressure:
0.186 hPa
Temp.:
30 °C
Vapour pressure:
0.463 hPa
Temp.:
50 °C
Vapour pressure:
1.634 hPa

Results

Results from calculation using loss of mass

Temperature [°C]

Vapour pressure [hPa]

20

0.18605

30

0.462615

50

1.633936

  

Calculation of the Reliance log p to 1/T

Formula of regression: log p [hPa] = -2943.25 1/T [1/K] + 9.33511

Temperature [°C]

log p [hPa]

1/T [K-1]

20

-0.73014

0.003411

30

-0.33478

0.003299

50

0.21324

0.003095

 

Results from calculation using formula of regression

 

Temperature

Estimated vapour pressure*

20 °C

0.2 hPa

50 °C

1.7 hPa

 

Conclusions:
Vapour pressure values of 0.2 hPa at 20°C and 1.7 hPa at 50°C were determined in a reliable study conducted according to an appropriate test protocol. It was not compliant with GLP.
Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).
Temp.:
25 °C
Vapour pressure:
8.6 Pa
Conclusions:
A vapour pressure value of 8.6 Pa at 25°C has been determined for the substance using an appropriate estimation method. The result is considered reliable.
Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).
Temp.:
25 °C
Vapour pressure:
0 Pa
Conclusions:
A vapour pressure value of 1.2E-04 Pa at 25°C has been determined for the substance using an appropriate estimation method. The result is considered reliable.

Description of key information

Vapour pressure (trimethoxy(2,4,4-trimethylpentyl)silane): 0.2 hPa at 20°C (measured)
Vapour pressure ((2,4,4-trimethylpentyl)silanetriol): 1.2E-04 Pa at 25°C (QSAR)
Methanol: 12790 Pa at 20°C (measured)

Key value for chemical safety assessment

Vapour pressure:
0.2 hPa
at the temperature of:
25 °C

Additional information

A vapour pressure value of 0.2 hPa at 20°C was determined by effusion method (Knudsen cell) according to EU Test Method A.4. A predicted vapour pressure of 0.086 hPa at 25°C was determined for the substance using an appropriate QSAR validation method and a measured vapour pressure value of < 10 hPa at 20 °C was obtained from a secondary source (company data).

The vapour pressure of the hydrolysis product was determined to be 1.2E-04 Pa at 25°C using a relevant estimation method method.

The measured vapour pressure of methanol is 12,790 Pa at 20°C (OECD, 2004).