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EC number: 247-279-7 | CAS number: 25811-35-2
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No experimental data on toxicity to terrestrial plants are
available for 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl
bisheptanoate (CAS 25811-35-2). The substance is characterised by a high
adsorption potential (log Koc > 5) and low water solubility (WS < 0.5
mg/L). Thus an exposure of plants is not anticipated as significant
quantities of the substance in pore water are unlikely. Generally a
chronic exposure of terrestrial organisms is not probable since the
substance is readily biodegradable and a rapid and ultimate degradation
in the terrestrial environment is anticipated. Toxic effects of the
substance to terrestrial organisms are not probable. This assumption is
supported by acute and chronic tests conducted with structurally
analogue substances decanoic acid, mixed esters with heptanoic acid,
octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9), fatty
acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS
68604-44-4) and fatty acids, C16-18 and C18-unsaturated, esters with
pentaerythritol (CAS 85711-45-1) on Eisenia fetida. The substances
caused neither mortality nor a decrease in the reproduction rate of
adult earthworms and thus a NOECmort/repro of ≥ 1000 mg/kg was reported
for the read across substances.
Thus, toxic effects of 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl
bisheptanoate (CAS 25811-35-2) to terrestrial plants are unlikely due to
the lack of exposure and the low toxicity as indicated by the available
experimental data. Additionally, the test substance is not expected to
remain in the terrestrial environment, due to ready biodegradation. A
relevant uptake and bioaccumulation in aquatic organisms is not expected
due to the low water solubility, rapid environmental biodegradation and
metabolisation via enzymatic hydrolysis. Enzymatic breakdown will
initially lead to the free fatty acid and the free alcohol (e. g.
pentaerythritol). This is supported by a low calculated BCF value of
0.895 L/kg ww (BCFBAF v3.01, Arnot-Gobas, including biotransformation,
upper trophic). Since the hydrolysis products are supposed to be
satisfactory metabolized in organisms, no potential for bioaccumulation
is to be expected. For more information on the metabolism of enzymatic
hydrolysis products please refer to IUCLID section 5.3, 6.3 or Chapter
4.3 Bioaccumulation. In accordance with Regulation (EC) No. 1907/2006,
Annex X, Column 2, 9.4 further studies on the effects on terrestrial
organisms do not have to be conducted since the chemical safety
assessment indicates that toxicity to terrestrial plants is not expected
to be of concern.
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