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Toxicity to terrestrial plants

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No experimental data on toxicity to terrestrial plants are available for 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 25811-35-2). The substance is characterised by a high adsorption potential (log Koc > 5) and low water solubility (WS < 0.5 mg/L). Thus an exposure of plants is not anticipated as significant quantities of the substance in pore water are unlikely. Generally a chronic exposure of terrestrial organisms is not probable since the substance is readily biodegradable and a rapid and ultimate degradation in the terrestrial environment is anticipated. Toxic effects of the substance to terrestrial organisms are not probable. This assumption is supported by acute and chronic tests conducted with structurally analogue substances decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9), fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) and fatty acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1) on Eisenia fetida. The substances caused neither mortality nor a decrease in the reproduction rate of adult earthworms and thus a NOECmort/repro of ≥ 1000 mg/kg was reported for the read across substances.
Thus, toxic effects of 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 25811-35-2) to terrestrial plants are unlikely due to the lack of exposure and the low toxicity as indicated by the available experimental data. Additionally, the test substance is not expected to remain in the terrestrial environment, due to ready biodegradation. A relevant uptake and bioaccumulation in aquatic organisms is not expected due to the low water solubility, rapid environmental biodegradation and metabolisation via enzymatic hydrolysis. Enzymatic breakdown will initially lead to the free fatty acid and the free alcohol (e. g. pentaerythritol). This is supported by a low calculated BCF value of 0.895 L/kg ww (BCFBAF v3.01, Arnot-Gobas, including biotransformation, upper trophic). Since the hydrolysis products are supposed to be satisfactory metabolized in organisms, no potential for bioaccumulation is to be expected. For more information on the metabolism of enzymatic hydrolysis products please refer to IUCLID section 5.3, 6.3 or Chapter 4.3 Bioaccumulation. In accordance with Regulation (EC) No. 1907/2006, Annex X, Column 2, 9.4 further studies on the effects on terrestrial organisms do not have to be conducted since the chemical safety assessment indicates that toxicity to terrestrial plants is not expected to be of concern.

 

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