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Toxicity to aquatic algae and cyanobacteria

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No toxic effects on aquatic algae up to the limit of water solubility. Read across

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Data on the acute toxicity of 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 25811-35-2) to aquatic algae are not available. In accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related substances fatty acids, C8-10 mixed esters with dipentaerythritol, isooctanoic acid, pentaerythritol and tripentaerythritol (CAS 189200-42-8) and fatty acids, C16-18 (even numbered), esters with pentaerythritol (CAS-No. 85116-93-4) was conducted. This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID Section 13.
The toxicity of fatty acids, C8-10 mixed esters with dipentaerythritol, isooctanoic acid, pentaerythritol and tripentaerythritol (CAS 189200-42-8) to algae was tested in a study according to OECD 201 under GLP conditions (Febbo, 1995). The green algae Scenedesmus capricornutum was exposed to nominal concentrations of 62.5 mg/L, 125 mg/L, 250 mg/L, 500 mg/L and 1000 mg/L. No inhibition of growth of Scenedesmus capricornutum up to the limit of water solubility was observed resulting in an EL50 > 1000 mg/L (nominal). A NOELR of ≥ 1000 mg/L (nominal) was determined based on effects on growth rate. Comparable results were obtained by a study investigating the toxicity of fatty acids, C16-18 (even numbered), esters with pentaerythritol (CAS-No. 85116-93-4) to algae. This static algal growth inhibition test with Pseudokirchnerella subcapitata was conducted according to GLP, and EPA OPPTS 850.5400 (Algal Toxicity, Tiers I and II). An ErL50 and ErL10 (72h) of > 100 mg/L was determined (WAF loading rate). Toxic effects on algae are not expected up to the water solubility for the read-across substance. Based on the available results from two structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 25811-35-2) will not exhibit short-term effects on aquatic algae up to the limit of water solubility.