Registration Dossier
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EC number: 247-279-7 | CAS number: 25811-35-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No chronic effects on aquatic invertebrates up to the limit of water solubility. Read across.
Key value for chemical safety assessment
Additional information
Data on the long-term toxicity of
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) to aquatic organisms are not available. Therefore, in
accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5, a read across
to the structurally related substance decanoic acid, mixed esters with
heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS No.
71010-76-9) was conducted. This read-across is justified in detail in
the overall summary (IUCLID section 6.1) and within the analogue
justification in IUCLID Section 13.
One study investigating the long-term toxicity of decanoic acid, mixed
esters with heptanoic acid, octanoic acid, pentaerythritol and valeric
acid (CAS No. 71010-76-9) to aquatic invertebrates is available
(Letinski & Bragin, 2012). The GLP study was conducted under semi-static
conditions according to OECD 211 using Daphnia magna as test organism. A
loading rate of 135 mg/L (nominal) was applied in the limit test. No
significant effect on reproduction was observed in the treatment
throughout the test period of 21 days. Hence, the 21 d-NOELR is
determined to be > 135 mg/L on the basis of the nominal test
concentration. No toxic effects on aquatic organisms were observed up to
the limit of water solubility. Based on the available results from a
structurally related read-across substance (in accordance to Regulation
(EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar
ecotoxicological profile and comparable structure, it can be concluded
that 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate
(CAS 25811-35-2) will not exhibit long-term effects on aquatic
invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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