Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-517-3 | CAS number: 61-76-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication published in a peer reviewed journal with limitations in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxizitatsunterschiede von Pharmaka bei subcutaner, intragastraler und intraduodenaler Applikation bei Ratten
- Author:
- Stockhaus, K. et. al.
- Year:
- 1 969
- Bibliographic source:
- Arch. Int. Pharmacodyn. 180:155 161.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Three groups of five rats were exposed to phenylephrine under light anesthesia of 3-4 minutes duration by oral gavage. The LD50 and the confidence limits were calculated according to Litchfield and Wilcoxon.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phenylephrine
- EC Number:
- 200-424-8
- EC Name:
- Phenylephrine
- Cas Number:
- 59-42-7
- IUPAC Name:
- 3-[1-hydroxy-2-(methylamino)ethyl]phenol
- Details on test material:
- - Name of test material (as cited in study report): Phenylephrine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: FW 49/Biberach
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-160g
- Fasting period before study: 12 hours
- Diet: Altromin-R-standard feed
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- No. of animals per sex per dose:
- 5
- Statistics:
- The LD50 and the confidence limits were calculated according to Litchfield and Wilcoxon.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 350 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 208 - 288
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
