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Long-term toxicity to aquatic invertebrates

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Description of key information

Based on long-term (chronic) toxicity study data, the test substance is very likely not harmful to aquatic organisms. No toxic effects occur within the range of solubility.

Key value for chemical safety assessment

Additional information

A GLP guideline study according OECD 211 using Daphnia magna has been conducted (BASF SE 2015). Due to the low solubility of the test item a saturated solution with a loading rate of 10 mg/L has been prepared and used in the limit test. However, the concentration of the test substance as a solution in test media could not be determined, since a reliable and specific method for analyses in the range of aqueous solubility could not be developed. Nevertheless, since all reasonable efforts were taken to produce a saturated solution of the test substance in test media, following the guidance in OECD 23, the test results should be based on loading concentration.

After 22 d of exposure no significant mortality, reduced reproduction or any other additional significant adverse effects or abnormal behavior were observed in any of the test treatments. Therefore, the NOEC after 22 d based on reproduction was determined to be ≥ 10 mg/L and the LOEC based on reproduction was determined to be > 10 mg/L after 22 d of exposure.

Hence, based on long-term (chronic) toxicity study data, the test substance is very likely not harmful to aquatic organisms. No toxic effects occur within the range of solubility.