Registration Dossier
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EC number: 205-286-2 | CAS number: 137-26-8
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to soil macroorganisms:
LC50 (14 d) = 540 mg a.i./kg soil dw (nominal, OECD 207, Eisenia fetida)
Long-term toxicity to soil macroorganisms:
NOEC (56 d, reproduction) = 8.45 mg a.i./kg soil dw (nominal, OECD 222, Eisenia fetida)
EC10 (56 d, reproduction) = 7.33 mg a.i./kg soil dw (nominal, OECD 222, Eisenia fetida)
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 7.33 mg/kg soil dw
Additional information
One key study on long-term and one supporting study on short-term toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to earthworms are available.
The available key study (2008) on long-term toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to mature earthworms (Eisenia fetida, 11 - 12 months old) was performed according to OECD Guideline No. 222 (GLP). Earthworms were exposed to Thiram 80 WG concentrations of 2.64, 5.27, 10.61, 21.22 and 42.44 mg test item/kg soil dry weight (nominal) equivalent to 2.1, 4.2, 8.45, 16.9 and 33.8 mg a.s./kg soil dry weight (nominal) for 4 weeks. In comparison to the control group, no significant effects on mortality and growth (biomass) of adult earthworms of all treatment groups were observed after four weeks of exposure. Thus a NOEC (28 d) values of ≥ 33.8 mg a.s./kg soil dw (nominal) were determined for mortality and growth (biomass), respectively. Concentration dependent effects on the reproduction of Eisenia fetida were observed after 56 d of exposure, resulting in a NOEC (56 d), EC10 (56 d) and EC50 (56 d) of 8.45, 7.33 and 24.29 mg a.i./kg soil dw (nominal).
The acute toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to earthworms was investigated in one supporting study (1993). This test was conducted according to OECD Guideline No. 207: Earthworm, Acute Toxicity Test (1984), under GLP conditions. After 14 days of exposure to tetramethylthiuram disulfide (CAS No. 137-26-8) spiked artificial soil, significant effects on survival of Eisenia fetida were observed at all concentrations tested except for the two lowest ones, resulting in an LC50 (14 d) of 540 mg a.i./kg (nominal).
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