Thiram

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

9 May 1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP - Guideline study

Qualifier:

according to guideline

Guideline:

other: OECD guideline 105

Deviations:

no

GLP compliance:

no

Medium:

other: dichloromethane

Solubility:

199 g/L

Temp.:

25 °C

Medium:

acetone

Solubility:

69.7 g/L

Temp.:

25 °C

Medium:

other: chloroform

Solubility:

204.7 g/L

Temp.:

25 °C

Medium:

other: xylene

Solubility:

9.1 g/L

Temp.:

25 °C

Medium:

benzene

Solubility:

41.2 g/L

Temp.:

25 °C

Reference 2

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14 February 1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP - Guideline study

Qualifier:

according to guideline

Guideline:

other: OECD guideline 105

Deviations:

no

GLP compliance:

no

Medium:

methanol

Solubility:

1.84 g/L

Temp.:

20 °C

Medium:

other: Petroleum ether 40-60

Solubility:

0.04 g/L

Temp.:

20 °C

Reference 3

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Date of experiment and analysis: 04.09.1997

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions (non-GLP)

Qualifier:

according to guideline

Guideline:

other: Determination was done by RP-HPLC

Deviations:

no

GLP compliance:

no

Medium:

ethyl acetate

Solubility:

13 g/L

Temp.:

22 °C

Reference 4

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01 October 1993-23 December 1993

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP - Guideline study

Qualifier:

according to guideline

Guideline:

other: OECD 105

Deviations:

no

GLP compliance:

yes

Medium:

acetonitrile

Solubility:

18.58 g/L

Temp.:

20 °C

Medium:

methanol

Solubility:

1.91 g/L

Temp.:

20 °C

Medium:

other: hexane

Solubility:

0.093 g/L

Temp.:

20 °C

Medium:

other: xylene

Solubility:

8.3 g/L

Temp.:

20 °C

Reference 5

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19 September 2005-06 April 2006

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study

Qualifier:

according to guideline

Guideline:

other: Determination was done by HPLC

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Medium:

acetone

Solubility:

21 g/L

Temp.:

20 °C

Medium:

ethyl acetate

Solubility:

8.53 g/L

Temp.:

20 °C

Medium:

other: dichloromethane

Solubility:

164 g/L

Temp.:

20 °C

Description of key information

The solubility of tetramethylthiuram disulfide in different organic solvents has been determined:
in Dichloromethane: 164 g/L at 20 °C and 199 g/L at 25 °C;
in Methanol: 1.84 - 1.91 g/L at 20 °C;
in Petroleum ether 40-60: 0.04 g/L at 20 °C;
in Ethyl acetate: 8.53 g/L at 20 °C and 13 g/L at 22 °C;
in acetone: 21 g/L at 20 °C and 69.7 g/L at 25 °C;
in acetonitrile: 18.58 g/L at 20 °C;
in Chloroform: 204.7 g/L at 25 °C;
in Xylene: 8.3 g/L at 20 °C and 9.1 g/L at 25 °C;
in Hexane: 0.093 g/L at 20 °C;
in Benzene: 41.2 g/L at 25 °C.