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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as- 2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
pH:
7
Hydrolysis rate constant:
0.042 s-1
DT50:
5.5 yr
Type:
second order
Remarks on result:
other: other details not available
pH:
8
Hydrolysis rate constant:
0.042 s-1
DT50:
200 d
Type:
second order
Remarks on result:
other: other details not available
pH:
7
Hydrolysis rate constant:
0.04 s-1
DT50:
5 yr
Type:
second order
Remarks on result:
other: other details not available
pH:
8
Hydrolysis rate constant:
0.04 s-1
DT50:
200 d
Type:
second order
Remarks on result:
other: other details not available
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 5 to 5.5 yr, at pH range 7 and 200 days at pH 8 by second order hydrolysis rate constant. Thus, based on this half-life value, it can be concluded that the test chemical not hydrolysable in water.
Executive summary:

Data available for the test chemical has been reviewed from authoritative database (HSDB, 2018) to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

In first weight of evidence study the base catalyzed second order hydrolysis rate constant of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.2 × 10-2 L/mol-sec with a corresponding half lives of 5.5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

In another study the base catalyzed second order hydrolysis rate constant and half life of hydrolysis of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.0 × 10-2L/mol-sec with a corresponding half lives of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 5 to 5.5 yr, at pH range 7 and 200 days at pH 8 by second order hydrolysis rate constant . Thus, based on this half-life value, it can be concluded that the test chemical not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 5 to 5.5  yr, at pH range 7 and 200 days at pH 8 by second order hydrolysis rate constant. Thus, based on this half-life value, it can be concluded that the test chemical not hydrolysable in water.

Key value for chemical safety assessment

Additional information

Data available for the test chemical has been reviewed from authoritative database (HSDB, 2018) to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

In first weight of evidence study the base catalyzed second order hydrolysis rate constant of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.2 × 10-2 L/mol-sec with a corresponding half lives of 5.5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

In another study the base catalyzed second order hydrolysis rate constant and half life of hydrolysis of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.0 × 10-2L/mol-sec with a corresponding half lives of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 5 to 5.5 yr, at pH range 7 and 200 days at pH 8 by second order hydrolysis rate constant . Thus, based on this half-life value, it can be concluded that the test chemical not hydrolysable in water.