Registration Dossier
Registration Dossier
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EC number: 212-414-0 | CAS number: 814-94-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- tin(II) oxalate
- IUPAC Name:
- tin(II) oxalate
- Reference substance name:
- Tin(II) oxalate
- EC Number:
- 212-414-0
- EC Name:
- Tin(II) oxalate
- Cas Number:
- 814-94-8
- Molecular formula:
- C2H2O4.Sn
- IUPAC Name:
- tin(II) oxalate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): tin (II) oxalate (obtained from Sigma-Aldrich Chemie GmbH (Steinheim, Germany))
- Purity: 98%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: WIST
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- > 1 - < 4 µm
- Geometric standard deviation (GSD):
- > 1.5 - < 3
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 20.7 mg/L; 8.24 mg/L; 2.97 mg/L
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- Concentration Mortality ratio
(mg/L) Males Females
5.0 3/3 3/3
1.0 2/3 1/3
0.5 0/3 0/3
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute median lethal concentration of the test article, Zinn (II) Oxalat, was found
to be 2 mg/L.
The test material was classified as Category 4 in respect of its acute inhalation toxicity
according to the Globally Harmonized System of Classification and Labelling of
Chemicals (GHS).
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