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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 July 1987 to 13 August 1987
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
EC Number:
219-094-1
EC Name:
1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
Cas Number:
2356-53-8
Molecular formula:
C3Cl2F6O
IUPAC Name:
1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
Constituent 2
Reference substance name:
Methylic Adduct
IUPAC Name:
Methylic Adduct
Details on test material:
- Name of test material (as cited in study report): Ethane,1,2-dichloro-1,1,2-trifluoro-2-trifluoromethoxy
- Substance type: pure substance
- Physical state: liquid
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Isomers composition: not reported
- Purity test date: not reported
- Lot/batch No.: F104206
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: in the dark under ambient conditions.

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
one single instillation (0.1 ml)
Observation period (in vivo):
1, 24, 48, 72 hours.
Number of animals or in vitro replicates:
3 (2 males + 1 female)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal: 1,2,3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
iris score
Basis:
animal: 1,2,3
Time point:
24/48/72 h
Score:
0
Max. score:
2
Remarks on result:
no indication of irritation
Irritation parameter:
conjunctivae score
Basis:
animal: 1,2,3
Time point:
24/48/72 h
Score:
0
Max. score:
3
Remarks on result:
no indication of irritation
Irritation parameter:
chemosis score
Basis:
animal: 1,2,3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
other: Conjunctival Discharge
Basis:
animal: 1,2,3
Time point:
24/48/72 h
Score:
0
Max. score:
3
Remarks on result:
no indication of irritation

Any other information on results incl. tables

In all animals, at all time points, no irritant responses were noted.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No irritant responses were noted.
It was concluded that 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is practically non-irritant to rabbit eyes
Executive summary:

The IRI project No.238237, includes an acute oral toxicity test, an eye irritation test and a dermal irritation test.

In the acute eye irritation test, three rabbits were treated with a single instillation of 0.1 ml of the test item.

The eyes were examined for irritation, using standard illumination, at 1, 24, 48 and 72 hours after instillation, using scoring system.

No corneal, iridial or conjunctival responses were noted.

It is concluded that 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is non-irritant to rabbit eyes.