Registration Dossier
Registration Dossier
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EC number: 939-718-2 | CAS number: 1474044-80-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
BCF fish estimated by QSAR: 3.16 L/kg wet weight.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.16 L/kg ww
Additional information
The bioaccumulation of the substance was assessed by using a validated QSAR model. As no definite measured logPow is available for the substance (measurements resulted in >6.6, which was the upper limit of validity of the method) and this value appeared too low for a meaningful prediction of a BCF the BCF was estimated by the BCF QSAR model applying the structure and molecular weight as input, estimating a logPOW (result was 22.4) and therefrom the estimated BCF-value being 3.16. This BCF value appears reasonable as the size of the molecule (1056.8 Dalton) would not lead to the expectation of significant bioaccumulation and thus is taken forward for hazard and risk assessment.
As the BCF is less than 500 the substance is not considered to significantly bioaccumulate in aquatic species.
Supporting evidence for the low bioaccumulation potential can be seen in the molecular weight (1057 Da) and the size of molecule (Dmax > 19 Angstroms). Molecules of this size are generally considered to have low bioaccumulation potential due to their reduced uptake and low membrane permeability (Guidance on information requirements and chemical safety assessment Chapter R.11: PBT Assessment).
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