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EC number: 237-167-6 | CAS number: 13676-91-0
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
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- Toxicological Summary
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- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,8-bis(phenylthio)anthraquinone
- EC Number:
- 237-167-6
- EC Name:
- 1,8-bis(phenylthio)anthraquinone
- Cas Number:
- 13676-91-0
- Molecular formula:
- C26H16O2S2
- IUPAC Name:
- 1,8-bis(phenylsulfanyl)-9,10-dihydroanthracene-9,10-dione
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Pa 243/244-22 bei 70 Grad getr.
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Animal species / strain quality: Rabbit/New Zealand White
Origin: Dr. K. Thomae GmbH, Biberach, FRG
Age of the animals: Young adult animals
Acclimatization period: at least for 1 week.
Housing: Stainless steel wire mesh cages with grating
Room temperature: 20 - 24 °C
Relative humidity: 30 - 70 %.
Day/night rhythm: 12 h/12 h (6.00 a.m. - 6.00 p.m.I 6.00 p.m. - 6.00 a.m.)
Type of cage: Stainless steel wire mesh cages with grating, floor area: 3000 cm2
No. of animals per cage: Single housing.
Animal identification: Ear tattoo
Bedding: No bedding in the cages; wood shavings in the waste trays.
Drinking water: About 250 ml tap water per animal per day
Diet: Kliba-Labordiaet, Klingentalmuehle AG Kaiseraugst, Switzerland, (about 130 g per animal per day)
Test system
- Vehicle:
- not specified
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml bulk volume
(about 26 mg of the comminuted test substance) - Duration of treatment / exposure:
- The test substance was applied in a single dose to the conjunctival sac of the right eyelid; the substance was washed out with tap water about 24 hours after application (before 24 hour reading).
- Observation period (in vivo):
- 1 h, 24 h, 48 h, 72 h, 8 d and 15 d after application.
- Number of animals or in vitro replicates:
- 3 rabbits
- Details on study design:
- Both eyes of the animal(s) were examined before application of the test material for signs of pre-existing irritation, reaction or abnormality which would prevent it from being used in the study.
Route of application: The test substance was applied in a single dose to the conjunctival sac of the right eyelid; the substance was washed out with tap water about 24 hours after application (before 24 hour reading).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 15 d
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 15 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24h
Any other information on results incl. tables
Individual eye scores
Animal No 1
Time point |
Cornea |
Iris |
Conjunctiva (Redness) |
Chemosis |
After 24 hours |
0 |
0 |
1 |
0 |
After 48 hours |
0 |
0 |
1 |
0 |
After 72 hours |
0 |
0 |
1 |
0 |
Mean (24-72 Hrs) |
0 |
0 |
1 |
0 |
Animal No 2
Time point |
Cornea |
Iris |
Conjunctiva (Redness) |
Chemosis |
After 24 hours |
0 |
0 |
2 |
1 |
After 48 hours |
0 |
0 |
1 |
0 |
After 72 hours |
0 |
0 |
1 |
0 |
Mean (24-72 Hrs) |
0 |
0 |
1.33 |
0.33 |
Animal No 3
Time point |
Cornea |
Iris |
Conjunctiva (Redness) |
Chemosis |
After 24 hours |
0 |
0 |
2 |
0 |
After 48 hours |
0 |
0 |
2 |
0 |
After 72 hours |
0 |
0 |
2 |
0 |
Mean (24-72 Hrs) |
0 |
0 |
2 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance Palanil Gelb HM f. ber. t. does not give indication of an irritant property to the eye.
- Executive summary:
An eye irritation study was carried out with Palanil Gelb HM f. ber. t. in NZW rabbits as per OECD Guideline 405. The potential of Palanil Gelb HM f. ber. t. to cause damage to the conjunctiva, iris or cornea was assessed in 3 White New Zealand rabbits, subjected to a single ocular application of 0.1 ml bulk volume (about 26 mg) of the test substance. The average score (24 to 72 hours) for irritation was calculated to be 0.0 for corneal opacity and for iris, 1.4 for conjunctival redness and 0.1 for chemosis. The findings were reversible in all animals within 15 days after application; thus the study was terminated. Symptoms observed and described in the respective observations together with the mean scores for irritation do not indicate an irritant property of the test substance to the eye. Under the test conditions chosen and considering the described findings Palanil Gelb HM f. ber. t. does not give indication of an irritant property to the eye.
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