Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Both in the absence and presence of S9-mix ZOR-F did not induce a statistically significant or biologically relevant increase in the number of cells with chromosome aberrations in two independent experiments with human lymphocytes. Moreover, ZOR-F tested in the Salmonella typhimurium reverse mutation assay and in the E. Coli reverse mutation assay in concentrations up to 5000 µg/plate did not express any mutagenic potential. All tests were considered valid. Thus, it is concluded that ZOR-F is not expressing genetic toxicity potential in vitro under the experimental conditions described.

Short description of key information:
In vitro genotoxicity of 7-aminodesacetoxycephalosporanic acid was tested in cultured human lymphocytes (chromosomal aberration) and in cultured E. Coli and S. Typhimurium cells (Ames test).

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification