Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 267-021-7 | CAS number: 67762-52-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 23 Mar - 25 Mar 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline 202 "Daphnia sp., Acute immobilisation Test and Reproduction Test" (1984)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom (date of inspection 23 Mar 1998)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control - 100 mg/L
- Sampling method: Water samples were taken from the control and the 100 mg/L loading rate WAF test group (replicates R1-R2 and R3-R4 pooled) at 0 and 48 h. Duplicate samples were taken at each occasion.
- Sample storage conditions before analysis: stored frozen (approx. -20 °C) for further analysis - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: An amount of test material (500 mg) was added to the vortex of 5 L of reconstituted water and stirred for 23 h to give the 100 mg/L loading rate. The stirring was stopped after 23 h and the mixture allowed to stand for 1 h. The water accommodated fraction (WAF) was then removed by filtration through 0.45 µm filters to give the 100 mg/L loading rate WAF.
- Controls: The control group was maintained under identical conditions but not exposed to the test material. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: supplied by the Institut National de Recherche Chimique Appliquée (IRCHA), France
- Age at study initiation: < 24 h
- Method of breeding: Adult Daphnia were maintained in polypropylene vessels containing approx. 2 L of reconstituted water in a temperature controlled room at 21 °C with a 16 h light and 8 h darkness cycle with 20 min dawn and dusk transition periods. The cultures were fed with a suspension of mixed algae (predominantly Chlorella spp.). Culture conditions ensured that reproduction was by parthenogenesis. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 21 °C
- pH:
- 7.9-8.0
- Dissolved oxygen:
- 8.0-8.3 mg O2/L
- Nominal and measured concentrations:
- Nominal concentrations: 100 mg/L loading rate WAF
- Details on test conditions:
- TEST SYSTEM
- Test vessel: jar
- Type: covered to reduce evaporation
- Material: glass; Size: 250 mL; Fill volume: 250 mL
- No. of organisms per vessel: 10
- No. of vessels per concentration: 4
- No. of vessels per control: 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
OTHER TEST CONDITIONS
- Photoperiod: 16 h light and 8 h darkness cycle with 20 min dawn and dusk transition periods
EFFECT PARAMETERS MEASURED: Immobilisation was measured after 24 and 48 h test duration.
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 10 and 100 mg/L loading rate WAFs
- Results used to determine the conditions for the definitive study: No immobilisation was observed. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: No mortality was observed
- Effect concentrations exceeding solubility of substance in test medium: The effect concentration exceeded the water solubility of the test substance.
Reference
No effects in the range of water solubility on immobilisation of Daphnia magna were observed after the study period of 48 h. This resulted in an EL50 of > 100 mg/L (nominal). Chemical analysis of the 100 mg/L loading rate WAFs at 0 and 48 h showed the measured test concentrations to be less than or at the limit of quantification of the analytical method. Increasing the time of stirring to 192 h did not result in a significant increase in the amount of carbon in the WAF with respect to the control values.
Table 1: Chemical analysis of test loading rates
Samples |
Nominal loading rate [mg/L] |
Concentration found [mg/L] |
0 h |
control |
< LOQ |
100 R1-R2 |
< LOQ |
|
100 R3-R4 |
0.00613 |
|
48 h |
control |
< LOQ |
100 R1-R2 |
< LOQ |
|
100 R3-R4 |
< LOQ |
Description of key information
No toxic effects to invertrbrates up to the limit of water solubility (WS: < 0.05 mg/L; OECD 203).
Key value for chemical safety assessment
Additional information
In accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the two structurally similar analogue substancesdipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9) andfatty acids C5-10 esters with dipentaerythritol (CAS 70983-72-1)was conducted to fulfil the data requirementsaccording to Annex VII-IX ofcarboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52 -1) in regard to toxicity to invertebrates.
This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID section 13. The source substances consist of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths as the target substance (C5-9 for the target substance compared to C5,9iso and C7-10 for the source substances, respectively).
The short-term toxicity to aquatic invertebrates with read across fatty acids C5-10 esters with dipentaerythritol was investigated according to OECD 202 using Daphnia magna as test organism under semi-static conditions. A nominal test concentration of 1060 mg/L (prepared as WAF) was tested. Analytical monitoring was not performed. No immobilisation was observed in the treatment throughout the test period of 48 h. Hence, the 48 h-EL50 is determined to be > 1060 mg/L. It can therefore be concluded that the test substance will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.
The study with the read across substancedipentaerythritol with fatty acids, C5 and C9iso was conducted under static conditions according to OECD 202 using Daphnia magna as test organism. Nominal concentration of 100 mg/L (prepared as WAF) was tested. Analytical monitoring showed that the measured test concentration was less than the limit of quantification. After 48 h no effects were observed. No mortality and no signs of intoxication were observed. Therefore, this study resulted in a 48 h EL50 of > 100 mg/L (nominal). The NOELR was derived to be ≥ 100 mg/L (nominal).
Based on the results from the substance itself and from a structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile, it can be concluded that fatty acids C5-10 esters with dipentaerythritol will not exhibit toxic effects to invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.