Registration Dossier
Registration Dossier
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EC number: 214-333-6 | CAS number: 1121-60-4
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 August - 2 September 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- (The Department of Health of the Government of the United Kingdom)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Pyridine-2-carbaldehyde
- EC Number:
- 214-333-6
- EC Name:
- Pyridine-2-carbaldehyde
- Cas Number:
- 1121-60-4
- Molecular formula:
- C6H5NO
- IUPAC Name:
- pyridine-2-carbaldehyde
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Pyridine-2-aldehyde
- Physical state: light yellow liquid
- Storage condition of test material: room temperature , in the dark until 31 July 2001 , thereafter approximately 4°C , under nitrogen , in the dark
Constituent 1
Study design
- Analytical method:
- gas chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 0.714
- Temp.:
- 20.5 °C
- pH:
- >= 6.4 - <= 6.8
Applicant's summary and conclusion
- Conclusions:
- The study was performed according to the EU method A.8 without deviations and therefore considered to be of the highest quality (reliability Klimisch 1).The validity criteria are fulfilled. The partition coefficient of the test material has been determined to be 5.17 at 20.5 ± 0.5°C, log10 Pow 0.714.
- Executive summary:
The test item was subjected to a shake-flask method test (GLP, 2001) to determine its partition coefficient. At approximately neutral pH a logPow of 0.714 (partition coefficient 5.17 at 20.5 ± 0.5°C) was identified.
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