Registration Dossier
Registration Dossier
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EC number: 292-474-2 | CAS number: 90622-71-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1996-10-22 to 1996-10-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study OECD 404, OECD 1981, updated guideline, adopted 1992. Deviation: The purity of the test substance is not mentioned
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Perfluoralkyljodid 612
- IUPAC Name:
- Perfluoralkyljodid 612
- Details on test material:
- - Molecular formula (if other than submission substance): C2F5(C2F4)nJ; (n= 2-5)
- Molecular weight (if other than submission substance): 530g/mol
- Physical state: violet fluid
- Analytical purity: n/a
- Impurities (identity and concentrations): n/a
- Composition of test material, percentage of components: n/a
- Lot/batch No.: P.96029
- Expiration date of the lot/batch: 1998-07-16
- Storage condition of test material: darkness at room temperature in a fume cupboard
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml per patch
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30-60 min, 24, 48 and 72 hours
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- #1, #2, #3
- Time point:
- other: 24h, 48h and 72h after patch removal
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: none
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this study the test substance is not irritating to skin
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