Registration Dossier
Registration Dossier
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EC number: 233-267-9 | CAS number: 10102-18-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: # 385 Peer-reviewed document from regulatory organisation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Profile For Selenium
- Author:
- U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry
- Year:
- 2 003
- Bibliographic source:
- http://www.atsdr.cdc.gov/toxprofiles/tp92.pdf
Materials and methods
Test material
- Reference substance name:
- Sodium selenite
- EC Number:
- 233-267-9
- EC Name:
- Sodium selenite
- Cas Number:
- 10102-18-8
- Molecular formula:
- H2O3Se.2Na
- IUPAC Name:
- disodium selenite
- Details on test material:
- - Name of test material (as cited in study report): Sodium selenite
Constituent 1
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The following oral LD50 values are reported (oral or gavage):
Rat (male): 7 mg/kg (Cummins and Kimura 1971)
Rat (male): 12.7 mg/kg (Vinson and Bose 1987)
Rat (female): 4.8 mg/kg (Pletnikova 1970)
Mouse (male): 3.2 mg/kg (Pletnikova 1970)
Mouse (male): 16 mg/kg ( Gao et al., 2000)
Mouse (female): 8.4 mg/kg ( Gao et al., 2000)
Guinea pig (female): 2.3 mg/kg ( Plasterer et al., 1985)
Rabbit (female): 1 mg/kg (Pletnikova 1970)
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