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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
The benzenediols: catechol, resorcinol and hydroquinone — a review of the industrial toxicology and current industrial exposure limits
Author:
C. W. FLICKINGER
Year:
1976
Bibliographic source:
American Industrial Hygiene Association Journal, 37:10, 596-606 1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Federal Hazardous Substances Act (FH S A) as published in the Federal Register of August 12, 1961 pages 7333-7341, entitled, "Part 19 1 - Hazardous Substances: Definitions and Procedural and Interpretative Regulations, Final Order.
Principles of method if other than guideline:
Data is from publication
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Resorcinol
Cas Number:
Resorcinol
Molecular formula:
C6H6O2
IUPAC Name:
Resorcinol
Constituent 2
Reference substance name:
1,3-Benzenediol
Cas Number:
108-46-3
Molecular formula:
C6H6O2
IUPAC Name:
1,3-Benzenediol
Constituent 3
Chemical structure
Reference substance name:
Resorcinol
EC Number:
203-585-2
EC Name:
Resorcinol
Cas Number:
108-46-3
Molecular formula:
C6H6O2
IUPAC Name:
1,3 benzenediol
Details on test material:
- Name of test material (as cited in study report):resorcinol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rabbit
Strain:
other: Albino
Sex:
male

Administration / exposure

Type of coverage:
open
Vehicle:
not specified
Details on dermal exposure:
The substance resorcinol was applied on the abraded skin and intact skin of rabbit
Duration of exposure:
24 hrs
Doses:
0, 1, 2, 3.98, 7.95 g/kg (0, 1000, 2000,3980,7950 mg/kg)
No. of animals per sex per dose:
no data
Control animals:
yes

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3 360 other: mg/kg
Based on:
test mat.
95% CL:
1 980 - 5 710
Mortality:
Mortality was observed during the 14 days observation period
Clinical signs:
other: The material produced necrosis of the skin in all of the rabbits exposed to the 7.95 and the 3.98 gm/ kg dosage levels, and in three of the four rabbits exposed to the 2.00 gm/ kg dosage level. The rabbits exposed to 1 .OO gm/ kg showed (only slight hyper
Gross pathology:
No internal gross lesions were observed upon autopsy off the sacrificed animals.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 value of resorcinol in albino rabbit during the 14 days observation period was found to be 3360 mg/kg
Executive summary:

The acute dermal LD50 value of resorcinol in albino rabbit during the 14 days observation period was found to be 3360 mg/kg. Thus according to the CLP criteria of aquatic classification it can be concluded that the substance resorcinol is not toxic via dermal route.