Registration Dossier
Registration Dossier
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EC number: 202-090-9 | CAS number: 91-68-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The effective concentration (EC50) value of 3-diethylaminophenol in Escherichia coli in a 12 hr study on growth effect was estimated to be 187.1003 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 187.1 mg/L
Additional information
Based on the various studies available with Klimish rating 2 for the target substance CAS NO 91-68-9 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
EC50 |
187.1003mg/l |
growth |
12 hrs |
Escherichia coli |
Predicted data for target chemical |
2 |
IGC50 |
41.6021 mg/l |
growth inhibition |
46 hrs |
Tetrahymena pyriformis |
Data is from DEPA |
3 |
EC50 |
7.8 mg/l |
no data |
24 hrs |
Nitrosomonas sp. |
Data from publication for CAS 108-46-3 |
4 |
IC50 |
1600 mg/l |
no data |
96 hrs |
methanogens |
Data from publication for CAS 108-46-3 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that IC50 value is expected to be in 41.6021 –1600 mg/l and EC50 value was found to be in the range of 7.8 to 187.1003 mg/l in 12 to 96 hrs study
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