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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Conducted with the hydrolysis product MPKO.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
not specified
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
not specified
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
ca. 34.7 g/L
Temp.:
19.8 °C
pH:
ca. 7.4
Conclusions:
The water solubility of the test substance was 34.7 g/L at 19.8 ± 0.5°C and a pH of 7.4.
Executive summary:

The flask method was chosen for the determination of the water solubility of MPKO in accordance with OECD Guideline 105 and EU Method A.6. The water solubility of the test substance at 19.8 ± 0.5°C was 34.7 g/L. The pH of the aqueous samples was 7.4.

Endpoint:
water solubility
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
The water solubility study was not performed because the substance is hydrolytically unstable in water (half-life time < 4 minutes). In accordance with Section 2 of REACH Annex XI, testing was omitted because it is technically not possible to conduct the study.
Reason / purpose:
data waiving: supporting information

Description of key information

The water solubility of the test substance cannot be determined due to the quick hydrolysis of the test substance (half life time < 4 minutes). The water solubility of MPKO, the hydrolysis product of OS2600, was determined to be 34.7 g/L at 19.8°C and pH of 7.4.

Key value for chemical safety assessment

Water solubility:
34.7 g/L
at the temperature of:
19.8 °C

Additional information

Data waiving (study technically not feasible): The water solubility study was not performed because the substance is hydrolytically unstable in water (half-life time < 4 minutes). In accordance with Section 2 of REACH Annex XI, testing was omitted because it is technically not possible to conduct the study.

Supporting study: The water solubility of the analogue substance MPKO was determined using the flask method in accordance with OECD Guideline 105 and EU Method A.6. The water solubility was 34.7 g/L at 19.8 ºC and pH of 7.4.