Registration Dossier

Administrative data

Description of key information

There was no acute toxicity report, but some information from repeated dose toxicity (Dhinsa N K and Brooks P, 2008) is considered as relevant to classification

Key value for chemical safety assessment

Additional information

There was no acute toxicity report, but some information from repeated dose toxicity (Dhinsa N K and Brooks P, 2008) is considered relevant to classification

At 1000 mg/kg out of a total of 6 animals there were 2 (humane) deaths on Day 1 and 4 (1 humane) deaths on Day 2 (just after second dosing). The cumulative dose on Day 2 was only 2000 mg/kg and this resulted in 100% death.

At 500 mg/kg there were 6 (all humane) deaths on Day 3. The cumulative dose on Day 3 was 1,500 mg/kg and this also resulted in 100% death.

Justification for classification or non-classification

According to the available information, the range of oral LD50 falls within the range of >300 -<=2,000 mg/kg (actual range is1050<LD50<2000 mg/kg/day).

Therefore in accordance with Regulation (EC) No. 1272/2008 Table 3.1.1 the substance is classified for Category 4 H302.