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Diss Factsheets
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EC number: 205-232-8 | CAS number: 136-23-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study, published in peer-reviewed literature, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Risk Assessments of Dithiocarbamate Accelerator Residues in Latex-based Medical Devices: Genotoxicity Considerations.
- Author:
- Tinkler J, Gott D and Bootman J
- Year:
- 1 998
- Bibliographic source:
- Food and Chemical Toxicology 36, 849-866
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- UKEMS Basic Mutagenicity Test Guidelines, 1990
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Zinc bis(dibutyldithiocarbamate)
- EC Number:
- 205-232-8
- EC Name:
- Zinc bis(dibutyldithiocarbamate)
- Cas Number:
- 136-23-2
- Molecular formula:
- C18H36N2S4Zn
- IUPAC Name:
- zinc bis(dibutyldithiocarbamate)
- Details on test material:
- - Name of test material (as cited in study report): zinc dibuthildithiocarbamate, ZDBC
- Physical state: fine white, aggregative powder
- Analytical purity: min. 98%
- Impurities (identity and concentrations): 28 ppm ZDMC, 17 pm ZDEC
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA 1535, TA 1537, TA1538, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S-9 homogenate from Aroclor 1254-induced adult male Sprague-Dawley rat livers
- Test concentrations with justification for top dose:
- 25, 79, 250, 790 and 2500 µg/plate; in additional experiment with TA100 2.5-250 µg/plate.
Controlsopen allclose all
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- Remarks:
- Migrated to IUCLID6: 2 µg/plate, without S9
- Positive controls:
- yes
- Positive control substance:
- benzo(a)pyrene
- Remarks:
- Migrated to IUCLID6: 5 µg/plate, with and without S9
- Details on test system and experimental conditions:
- The test design included a preliminary toxicity test and a mutation assay using the standard pour plate procedure, followed by an independent repeat experiment. An additional assay in TA 100 was performed at lower concentrations (2.5-250 µg/plate) in view of the toxicity seen in the first mutation experiment with this strain.
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium, other: TA98, TA100, TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- at 2500 µg/plate; at TA100 also at 250 and 790 µg/plate
- Additional information on results:
- Inhibition growth was seen in all strains at the highest dose tested (also at 250 and 790 µg/plate in TA100). There was no increase in the number of revertants observed in any strain, in either presence or absence of S9-mix.
Any other information on results incl. tables
Mean numbers of revertants observed in Salmonella typhimurium TA 100 cultures following exposure to ZDBC at various concentrations.
|
|
|
Mean revertants (+/- SD) |
|
Test substance |
Concentration (µg/plate) |
Activation system |
Experiment 1 |
Experiment 2 |
ZDBC |
2.5 |
- |
NT |
117 +/-5 |
7.9 |
- |
NT |
106 +/- 14 |
|
25 |
- |
149 +/- 12 |
100 +/- 5 |
|
79 |
- |
109 +/-7 |
97 +/- 8 |
|
250 |
- |
140 +/- 4* |
110 +/- 22* |
|
790 |
- |
90 +/- 57* |
64 +/- 4 |
|
2500 |
- |
21 +/- 22** |
18 +/-3* |
|
2.5 |
+ |
NT |
95 +/- 8 |
|
7.9 |
+ |
NT |
112 +/-6 |
|
25 |
+ |
147 +/-31 |
112 +/- 16 |
|
79 |
+ |
118 +/- 79 |
121 +/- 13 |
|
250 |
+ |
43 +/- 40* |
94 +/- 11* |
|
790 |
+ |
32 +/- 9* |
49 +/- 28* |
|
2500 |
+ |
30 +/- 8* |
16 +_/- 6* |
|
DMSO |
|
- |
135 +/- 9 |
127 +/- 7 |
DMSO |
|
+ |
120 +/-6 |
127 +/- 8 |
Sodium azide |
2 |
- |
683 +/-95 |
963 +/- 74 |
Benzo[α]pyrene |
5 |
- |
132 +/- 25 |
115 +/-10 |
Benzo[α]pyrene |
5 |
+ |
606 +/- 109 |
766 +/- 60 |
NT = not tested; *= toxic effect on tester strain was evident.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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