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Short-term toxicity to fish

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Description of key information

No toxic effects up to the limit of water solubility for Cyprinus carpio (OECD 203)

Key value for chemical safety assessment

Additional information

There are no studies available on the toxicity of isopentyl laurate (CAS No. 6309-51-9) on fish. The assessment of fish toxicity was therefore based on studies conducted with the structurally similar substances isooctyl ester (CAS No. 84713-06-4) and isopropyl myristate (CAS No. 110-27-0), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.

The key study with dodecanoic acid isooctyl ester (CAS No. 84713-06-4) was performed according to OECD guideline 203 and GLP (Bogers, 1997). The test organism Cyprinus carpio was exposed to the test substance in a static system for 96 hours, at the nominal test concentration of 10,000 mg/L. Only the separated water phase was used in the test solutions. No mortality occurred at any of the test concentrations, and the LC50 was reported to be > 10,000 mg/L.

The key study with isopropyl myristate (CAS No. 110-27-0) was performed according to the guideline EPA 660/3-75-009 (1975) (Sousa, 1979). The test organism Lepomis macrochirus was exposed to the test substance in a static system for 96 hours, at the nominal test concentrations of 78, 130, 220, 360, 600 and 1000 mg/L. No mortality occurred at any of the test concentrations during the test period, and the LC50 was reported to be > 1000 mg/L.

Thus, based on theabove mentioned results, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on fish are expected up tothe limit ofwater solubility for isopentyl laurate (CAS No. 6309-51-9).