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Diss Factsheets
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EC number: 200-592-2 | CAS number: 64-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: publication with well documented information
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- rats were laparotomized and various agents were injected into the uterine horns.
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- Demeclocycline
- EC Number:
- 204-834-8
- EC Name:
- Demeclocycline
- Cas Number:
- 127-33-3
- IUPAC Name:
- 7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Adult fenale Sprague-Dawley rats were housed in a standardized lighting environment (14 hr on; 10 hr off) and fed and watered ad libitum. Vaginal smears were observed to document cyclic activity and rats in the diestrus phase of the cycle were used for study.
Administration / exposure
- Route of administration:
- other: rats were laparotomized and various agents were injected into the uterine horns.
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Under ethyl ether anesthesia, rats were laparotomized and various agents were injected into the uterine horns. Injections were made in the right horn by grasping the cervical end of that horn with forceps and inserting a 21-gauge needle into the.lumen and a 0.2 ml volume of test substance was Injected via a tuberculin syringe. The horn was held with forceps for 30 seconds after injection to prevent reflux.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 14days
- Frequency of treatment:
- one treatment
- Duration of test:
- 14days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
drugs and control(saline)
Basis:
actual ingested
10 mg
- No. of animals per sex per dose:
- 5
- Control animals:
- other: saline(0.2 ml)
- Details on study design:
- The abdominal wall was sutured and the skin closed with wound clips. Two weeks later the animals were necropsied. The treated and non-treated uterine horns were fixed for histology and stained with hematoxylin and eosin.
Microscopic sections of the uterine horn were evaluated by an observer unaware of the treatment who scored the morphologic appearance as normal or abnormal. An abnormal section was one demonstrating epithelial or stromal necrosis, scarring, or inflammation. - Statistics:
- no data
Results and discussion
Observed effects
Applicant's summary and conclusion
- Conclusions:
- Based on the available data in this report, test material can cause uterine morphology changes but no mortality in the rats.
- Executive summary:
This study was conducted to screen other drugs for their uterine morphology in the rats. The drugs tested include quinacrine-like compounds, and tetracycline and its analogues(exp. test article) which are known sclerosing agents. Tetracycline and its analogues produced quinacrine-like morphologic changes in the rat and showed no toxicity for the dose tested. It was indicated that no mortality but uterine necrosis was observed with test material.
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