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EC number: 201-077-5 | CAS number: 78-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well-documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Bioorganotin Chemistry. Metabolism of Organotin Compounds in Microsomal Monooxygenase Systems and in Mammals
- Author:
- Kimmel EC, Fish RH & Casida JE
- Year:
- 1 977
- Bibliographic source:
- Journal of Agriculture and Food Chemistry, 25 (1): 1-9
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- The metabolic fate of dibutyltin acetate was examined in a microsomal monooxygenase metabolism system (MO) derived from either rat or rabbit livers. Comparative data was also provided on other alkyltins in the MO system.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- dibutyltin diacetate
- IUPAC Name:
- dibutyltin diacetate
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- Bu2Sn(OAc)2: 6.3 Ci/mmol
Administration / exposure
- Vehicle:
- ethanol
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.003 µmol of [14C]butyltin derivative
0.5 µmol of unlabeled compound
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Unlabeled Bu2SnX2 undergoes NADPH-dependent conversion to BuSnX3 (TLC cochromatography in D & E) no other products detected with rabbit microsomes, while [14C]Bu2SnX2 yields one polar NADPH-dependent metabolite and no BuSnX3with rat microsome.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- [14C]Butyltin Derivatives and Rat Liver Microsome-NADPH System:-
Metabolites of [I4C]-Bu2Sn(OAc)2 were analysed in a series of chromatographic systems that resolve all of the authentic unlabeled compounds and therefore allow tentative metabolite identification by cochromatography and quantitation by lsc. [14C]Bu2Sn(OAc)2 yields one NADPH-dependent metabolite (free, polar) in a small amount but the formation of BuSnX3does not appear to be dependent on NADPH fortification.
Unlabeled n-Alkyltin Derivatives and Rabbit Liver Microsome-NADPH System:-
Unlabeled Bu2SnX2 undergoes NADPH-dependent conversion to BuSnX3 (TLC cochromatography in D and E) but no other products are detected with rabbit microsomes, while [14C]Bu2SnX2 yields only one polar NADPH-dependent metabolite and no BuSnX3with rat microsomes.
Any other information on results incl. tables
Properties and Optimization of Monooxygenase System.
Rat liver microsomal preparations were used with 14C-labeled substrates and rabbit liver microsomes with unlabeled substrates, unless noted otherwise. With both rat and rabbit preparations, a small amount of soluble fraction (optimum 40-100 mg fresh liver weight equivalent) increases the activity of the microsome-NADPH system although the soluble fraction is not active by itself or with NADPH. There is a considerable variation in the activity of different enzyme preparations from the same species, for unknown reasons. It is necessary in all cases to fortify the microsomal preparations with NADPH to obtain detectable metabolism of the organotin and organolead substrates. (The rat liver microsome-NADPH system acting on [14C]Bu3SnOAc is totally inhibited by carbon monoxide and to a large extent by 4(5)-a-naphthylimidazole, which suggests that a cytochrome P450 dependent monooxygenase system is responsible for metabolism of the organometallic substrates.)
Applicant's summary and conclusion
- Conclusions:
- Metabolism of Bu2Sn(OAc)2 yields BuSnX3, possibly by both nonenzymatic destannylation and by a- and β-carbon hydroxylation and decomposition of the hydroxy derivatives. The unidentified polar metabolites are probably formed by two or more sites of hydroxylation at different butyl groups. Bu3SnX and Bu2SnX2 bind extensively in some tissue fractions, making analysis difficult analysis and a plausible explanation for the relatively low metabolite yields.
- Executive summary:
The metabolic fate of dibutyltin acetate was examined in a microsomal monooxygenase metabolism system (MO) derived from either rat or rabbit livers. Comparative data was also provided on other alkyltins in the MO system.
Metabolism of Bu2Sn(OAc)2 yields BuSnX3, possibly by both nonenzymatic destannylation and by a- and β-carbon hydroxylation and decomposition of the hydroxy derivatives. The unidentified polar metabolites are probably formed by two or more sites of hydroxylation at different butyl groups. Bu3SnX and Bu2SnX2 bind extensively in some tissue fractions, making analysis difficult analysis and a plausible explanation for the relatively low metabolite yields.
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