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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

No data is available on the substance regarding the long term toxicity on invertebrates. Nevertheless, a reliable key study (Harlan, 2013) is available for an analogous substance. The substance was studied in a 21-day semi static test on Daphnia magna in accordance with the OECD Guideline, No. 211 and in compliance with GLP. 
Based on the effect on survival and reproduction, the 21-day NOEC (daphnia magna) was determined to be 2.9 mg/L (corresponding to 1.05 mg active ingredient/L, both concentrations are mean measured).

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
1.05 mg/L

Additional information

No data is available on the substance regarding the long term toxicity on invertebrates. Nevertheless, a reliable key study (Harlan, 2013) is available for an analogous substance, Mackam CBS-50GE. The analogous substance is an aqueous solution at 36.2% of Cocamidopropyl hydroxysultaine with C8-18 alkyl chain length distribution, with a majority of C12 and C14 alkyl chains. Cocamidopropyl hydroxysultaine C8-18 and Lauramidopropyl hydroxysultaine have the same functional groups, and general composition. The main variable resides in the alkyl chain distribution. The main component in Cocamidopropyl hydroxysultaine C8-18 is C12 fraction (C12 alkylamidopropylhydroxysultaine) as in Lauramidopropyl hydroxysultaine.

The substance was studied in a 21-day semi static test onDaphnia magnain accordance with the OECD Guideline, No. 211, Daphnia magna Reproduction Test and in compliance with the Principles of Good Laboratory Practice Regulations.

Based on the effect on survival and reproduction, the 21-day NOEC (Daphnia magna) was determined to be 2.9 mg/L (corresponding to 1.05 mg active ingredient/L, both concentrations are mean measured).

Based on the mortality, the 21-day LOEC was determined to be 10.6 mg/L (corresponding to 3.9 mg active ingredient/L, both concentrations are mean measured), due to the 100% mortality of Daphnia magna at this concentration.

The 21-day EC values for the inhibition of the reproduction rate could not be calculated since no effect was determined on the reproduction of the daphnids up to and including the mean measured test concentration of 2.9 mg/L (corresponding to 1.05 mg active ingredient/L).

All the validity criteria are fulfilled.