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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

In two reliable studies on freshwater and marine water invertebrates, 48-hour EC50 (Daphnia magna) was calculated to be 9.3 mg/L (4 mg active ingredient/L) on an analogous substance and 48-hour LC50 (Acartia tonsa) was calculated to be 66.75 mg/L (30 – 33.4 mg active ingredient/L) for the MACKAM LSB-50.
According to the data, the lauramidopropyl hydroxysulaine is considered as toxic to the aquatic invertebrates under the test conditions.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
4 mg/L
EC50/LC50 for marine water invertebrates:
30 mg/L

Additional information

One reliable key study (Opus, 2009) is available for marine water invertebrates and one reliable key study on an analogous substance (Rhodia, 1994) is available for freshwater invertebrates.

 

 -Key study, marine water invertebrates: The test with MACKAM LSB-50 on marine copepod (Acartia tonsa) was determined in a 48-hour static test according to GLP requirements and the ISO 14669 (1999) Water Quality - Determination of acute lethal toxicity to marine copepods (Copepoda; Crustacea).

The 48-hour EC50 was calculated to be 66.75 mg/L and the 48 -hour EC50 expressed as 100% active ingredient (lauramidopropyl hydroxysultaine) was found to be 30 – 33.4 mg/L.

 

-Key study, freshwater invertebrates: The test with MIRATAINE CBS on invertebrates (Daphnia magna) was determined in a 48 -hour static test according to the EU Method C.2 (Acute Toxicity for Daphnia). MIRATAINE CBS is an aqueous solution at 43.5% of Cocamidopropyl hydroxysultaine /C12-18 alkyl chain length distribution. Cocamidopropyl hydroxysultaine C8-18 and Lauramidopropyl hydroxysultaine have the same functional groups, and general composition. The main variable resides in the alkyl chain distribution. The main component in Cocamidopropyl hydroxysultaine C8-18 is C12 fraction (C12 alkylamidopropylhydroxysultaine) as in Lauramidopropyl hydroxysultaine.

The 48-hour EC50 was calculated to be 9.3 mg/L of test item and the 48 -hour EC50 expressed as 100% active ingredient was found to be 4 mg/L.

 

For these 2 studies, the validity criteria were met.

 

According to the data, the lauramidopropyl hydroxysulaine is considered astoxic to the aquatic invertebratesunder the test conditions.