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EC number: 237-163-4 | CAS number: 13676-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 July 2012 - 11 January 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- EC No. 440/2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP certificate: June 2012
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: At each sampling time, duplicate vials were removed from the waterbath and the entire volume was extracted with three portions (5 ml) of dichloromethane. The extracts were combined and evaporated to dryness under nitrogen and the residue redissolved in acetonitrile (1 mL) for analysis by high performance liquid chromatography (HPLC).
- Sampling intervals/times for pH measurements: Immediately and then after 2.4 hours
- Sample storage conditions before analysis: The samples were placed in a waterbath at 50°C in the dark until sampling was required (immediately and then after 2.4 hours, for pH 4 and pH 7) - Buffers:
- - pH: 4, 7 and 9
- Composition of buffer:
pH 4: 0.2M aqueous potassium dihydrogen orthophosphate (550 mL) was mixed with 0.07M aqueous disodium hydrogen orthophosphate dodecahydrate (1250 mL) and purified water (3200 mL). The pH was adjusted to 4.0 +/- 0.05 with orthophosphoric acid.
pH 7: 0.2M aqueous potassium dihydrogen orthophosphate (1250 mL) was mixed with 1M sodium hydroxide (150 mL) and purified water (3600 mL). The pH was adjusted to 7.0 +/- 0.05 with 1M hydrochloric acid/1M sodium hydroxide, as required.
pH 9: 0.1M boric acid in 0.1M aqueous potassium chloride (2500 mL) was mixed with 1M sodium hydroxide (105 mL) and purified water (2400 mL). The pH was adjusted to 9.0 +/- 0.05 with 1M hydrochloric acid/1M sodium hydroxide, as required. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks: Wheaton vials containing buffer solution (9 mL). Vials were purged with nitrogen and pre-equilibrated at test temperatures (50 °C)
- Extended testing at pH 4 and pH 7:
* Separate tests were conducted at temperatures of 10, 25 and 40 °C in the dark. Duplicate samples were taken immediately to serve as t0 samples, and then several pairs of samples were analysed in the range of 10 to 90% hydrolysis to test for pseudo-first order behaviour.
- Extended testing at pH 9:
* As the hydrolysis rate was extremely rapid, testing was conducted at the single reporting temperature of 25 °C and with reduced sampling (four samples at each of t0 and t5minutes). - Number of replicates:
- 2 at each sampling time
- Preliminary study:
- The preliminary study showed that at each of pH 4, pH 7 and pH 9 at 50 ± 0.5°C, more than 10% hydrolysis had occurred after 2.4 hours.
- Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- 12 h
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 2 h
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 5 min
- Details on results:
- - Extended testing at pH 4: At pH 4, definitive tests were conducted at temperatures of 10, 25 and 40˚C, and the hydrolysis rate constant (k) and DT50 at 25˚C were extrapolated from the measured values of log10k at the selected temperatures using the Arrhenius relationship. A DT50 value of 12 hours was obtained at this pH value. The hydrolysis reactions for BMI at pH 4 were shown to follow pseudo-first order behaviour.
- Extended testing at pH 7: At pH 7, definitive tests were conducted at temperatures of 10, 25 and 40˚C, and the hydrolysis rate constant (k) and DT50 at 25˚C were interpolated from the measured values of log10k at the selected temperatures using the Arrhenius relationship. A DT50 value of 2 hours was obtained at this pH value. The hydrolysis reactions for BMI at pH 7 were shown to follow pseudo-first order behaviour.
- At pH 9, testing was conducted at the single temperature of 25˚C. The DT50 value of less than 5 minutes was obtained at this pH value. - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of this test BMI was determined to be hydrolytically unstable under acidic, neutral and basic conditions, the rate of the reaction increasing with increase in pH.
- Executive summary:
A study was performed to determine the rate of hydrolysis of BMI as a function of pH. The study was performed according to GLP principles and met the requirements of Commission Regulation (EC) No. 440/2008, Method C.7, and the OECD Guidelines for Testing of Chemicals, Method 111.
Under the conditions of this test BMI was determined to be hydrolytically unstable under acidic, neutral and basic conditions, the rate of the reaction increasing with increase in pH. A DT50 value of 12 hours was obtained at pH 4, 2 hours at pH 7 and a DT50 value of less than 5 minutes was obtained at pH 9.
Reference
Description of key information
pH 9: DT50 = < 5 mins at 25 °C
pH 7: DT50 = 2 hours at 25 °C
pH 4: DT50 = 12 hours at 25 °C
Key value for chemical safety assessment
Additional information
A study was performed to determine the rate of hydrolysis of BMI as a function of pH. The study was performed according to GLP principles and met the requirements of Commission Regulation (EC) No. 440/2008, Method C.7, and the OECD Guidelines for Testing of Chemicals, Method 111.
Under the conditions of this test BMI was determined to be hydrolytically unstable under acidic, neutral and basic conditions, the rate of the reaction increasing with increase in pH. A DT50 value of 12 hours was obtained at pH 4, 2 hours at pH 7 and a DT50 value of less than 5 minutes was obtained at pH 9.
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