Registration Dossier
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EC number: 941-129-0 | CAS number: 1407974-32-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48-h acute toxicity of the test item to Daphnia magna was studied under semi-static conditions in a GLP study performed according to OECD TG 202 and EC Method C.2. The 48-h EC50 was > 100 mg/L and the NOEC was 100 mg/L, based on nominal concentrations.
Key value for chemical safety assessment
Additional information
One study is available. In this study, performed under GLP according to OECD TG 202 and EC Method C.2, twenty daphnids (4 replicates of 5 animals) were exposed to an aqueous dispersion of the test item at a concentration of 100 mg/L for 48 hours at a temperature of 20 °C under semi-static test conditions. Immobilization and any adverse reactions to exposure were recorded after 24 and 48 hours.Analysis of the freshly prepared test preparations at 0 and 24 hours showed that measured concentrations of 57% and 68% or nominal were obtained respectively, and analysis of the old or expired test preparations at 24 and 48 hours showed that measured test concentrations of 49% and 61% of nominal value were obtained respectively. As the test item concentrations were calculated by monitoring and analyzing for only one component of the test item, the low percentage nominal values could be attributed to the solubility/stability of that single component and not the test item as a whole. Given that the toxicity cannot be attributed to a single
component or a mixture of components, but to the test item as a whole, the results were based on nominal concentrations only.
Exposure of Daphnia magna to the test item gave an EC50 value based on nominal concentrations of greater than 100 mg/L. The No Observed Effect Concentration was 100 mg/L.
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