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Administrative data

Endpoint:
nanomaterial dustiness
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 Jul 2020 - 16 Sep 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Remarks:
According to DIN EN 17199-3

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DIN EN 17199-3
Version / remarks:
DIN EN 17199-3:2019-12 “Workplace exposure - Measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method
Deviations:
yes
Remarks:
1 measurement performed
GLP compliance:
no
Type of method:
continuous drop
Sampling:
The test material was used without further treatment (e.g. drying). The relative humidity of the test atmosphere was 51%. 59.4 g (259.4 cm³) test material was used for the measurement, at a dosing rate of 5.94 g/min. 1 measurement was performed for background and sample, with a measurement duration of 3 and 10 minutes, respecitvely.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[(4-chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide
EC Number:
236-852-7
EC Name:
2-[(4-chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide
Cas Number:
13515-40-7
Molecular formula:
C17H15ClN4O5
IUPAC Name:
2-[(4-chloro-2-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide
Test material form:
solid: nanoform, no surface treatment

Results and discussion

Dustiness indexopen allclose all
Key result
Mean:
37 366 other: particles/mg
Remarks on result:
other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)
Mean:
4 188 other: particles/cm³
Remarks on result:
other: number of airborne nanoparticles per cm³, size range 10-100 nm

Any other information on results incl. tables

The cleaned, almost particle-free air had a total particle count of 6 particles/cm³ in the range of 10 nm – 417 nm, whereby the nanoscale fraction (10 - 100 nm) contained 4 particles/cm³.


 


Summary SMPS result:


































Range


[nm]



Mean


[nm]


 



 


Concentration


[ particles /cm³]



I(CD)


[particles/mg]


 



E(CD)


[1/mg·s]



 10 -100



 73.1



 4187.8



37365.8



62.3



 100 - 417



 186.7



16277.7



145238.4



242.1


 10 - 417 163.520465.4182604.2304.3

 


Summary OPS result:




















Range


[µm]



Mean


[µm]


 



 


Concentration


[ particles /cm³]



I(CD)


[particles/mg]


 



E(CD)


[1/mg·s]



 0.3 - 10



 5.6



 95.7



854.2



1.4



 


ICD: dustiness index as number of airborne particles per mg


ECD: emission rate as number of particles per mg per second


mean: average particle diameter in nm


N: number of airborne particles

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199-3:2019-12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Continuous drop method".


The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by clean, almost particle-free air.


The SMPS counted 4188 particles in the nanoscale (10 - 100 nm) per cm³, corresponding to a dustiness index of 37366 particles in the nanoscale (10 - 100 nm) per mg. The particle number in the whole SMPS size range (10-417 nm) was 16278 per cm³, corresponding to a dustiness index of 145238 particles/mg (size 10 - 417 nm).


The mean size of the nanoparticles was 73.1 nm, the mean size of particles in the range 10 - 417 nm was 186.7.


The OPS (0.3 - 10 µm) counted 95.7 particles per cm³ corresponding to a dustiness index of 854 particles per mg. The mean size of the particles was 5.6 µm.