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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Water solubility:
48.94 mg/L
20 °C
Remarks on result:
other: pH value was not determined

In a preliminary study, the solubility of the test item in water could be estimated as Iying between 10 and 100 mg/L, approx. 40 mg/L.

In the main study, 400-410 mg/L were weighed into each of six individual vessels, water was added, and the vessels were shaken at 20 ± 0,5 °C.

On the days 3, 4, 5 and 6, vessel 1 was taken fram the shaking apparatus and stored at 20 ± 0.1 °C for equilibration. Samples were taken, filtrated and analysed using HPLC as shaking of the test vessels was continued.

No differences above 15% in the concentration of the solution could be determined between the sampling dates 1, 2, 3 and 4, supporting the hypothesis, that the maximum concentration of the test item had been reached. Therefore, on day 6, vessels 2 - 6 were

sampled and analysed in the same fashion.

At the plateau, the concentration of N,N'-hexane-1 ,6-diylbis(hexahydro-2-oxo-1 H-azepine-1-carboxamide) in water had reached

48.94 ± 1.11 mg/L at 20 ± 0.5 °C = 4.894 ± 0.111 * 10.5 kg/L (SI units)

(mean value ± standard deviation of six individual vessels)

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility: ca. 49 mg/L at 20 °C.
Executive summary:

The solubility in water was determined to be:

48.94 ± 1.11 mg/L at 20 ± 0.5 °C.

Description of key information

The substance is sparingly soluble in water.

Key value for chemical safety assessment

Water solubility:
48.94 mg/L
at the temperature of:
20 °C

Additional information

The water solubility was determined to be: 48.94 ± 1.11 mg/L (at 20 ± 0.5 °C).