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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature. Original reference in Russian. Documentation insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Toxicity of 1,2-dimethoxybenzene Gigiena Truda i Professional'nye Zabolevaniya.
Author:
Grodetskaia, V.S., Drobyshevskaia, G.L., and Kondaurova, G.L.
Year:
1982
Bibliographic source:
Labor Hygiene and Occupational Diseases. Vol. 26(2), Pg. 54. (Reference: Information from the Soviet Toxicology Centre 613.632.547.52/59)

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Veratrole
EC Number:
202-045-3
EC Name:
Veratrole
Cas Number:
91-16-7
Molecular formula:
C8H10O2
IUPAC Name:
1,2-dimethoxybenzene
Test material form:
not specified
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
0.25 and 1.25 g/kg bw
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
700 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality occurred at a dose level of 25 mg/kg and 100% mortality was observed at 1250 mg/kg. The LD50 was calculated as 700 or 890 mg/kg.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Veratrole is harmful in contact with skin.