Registration Dossier
Registration Dossier
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EC number: 202-045-3 | CAS number: 91-16-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature. Original reference in Russian. Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of 1,2-dimethoxybenzene Gigiena Truda i Professional'nye Zabolevaniya.
- Author:
- Grodetskaia, V.S., Drobyshevskaia, G.L., and Kondaurova, G.L.
- Year:
- 1 982
- Bibliographic source:
- Labor Hygiene and Occupational Diseases. Vol. 26(2), Pg. 54. (Reference: Information from the Soviet Toxicology Centre 613.632.547.52/59)
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- other: no data
Test material
- Reference substance name:
- Veratrole
- EC Number:
- 202-045-3
- EC Name:
- Veratrole
- Cas Number:
- 91-16-7
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 1,2-dimethoxybenzene
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- No data
- Doses:
- 0.25 and 1.25 g/kg bw
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality occurred at a dose level of 25 mg/kg and 100% mortality was observed at 1250 mg/kg. The LD50 was calculated as 700 or 890 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Veratrole is harmful in contact with skin.
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