Registration Dossier
Registration Dossier
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EC number: 202-045-3 | CAS number: 91-16-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference in foreign language (Czech language) and documentation is insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Phenol metabolism in guinea pigs
- Author:
- Bardodej Z. and Krivucova M.
- Year:
- 1 961
- Bibliographic source:
- Cslka Hyg., 6(9), 553-554
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Guideline:
- other: No data. If any guideline was followed, no details are given.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Veratrole
- EC Number:
- 202-045-3
- EC Name:
- Veratrole
- Cas Number:
- 91-16-7
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 1,2-dimethoxybenzene
- Details on test material:
- No data
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not known
Administration / exposure
- Route of administration:
- other: not known
- Vehicle:
- not specified
- Details on exposure:
- Not known
- Duration and frequency of treatment / exposure:
- Not known
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not known
- No. of animals per sex per dose / concentration:
- Not known
- Control animals:
- not specified
- Positive control reference chemical:
- Not known
- Details on study design:
- Not known
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- No other information - Statistics:
- Not known
Results and discussion
- Preliminary studies:
- Not applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not applicable
- Details on distribution in tissues:
- Not applicable
- Details on excretion:
- Not applicable
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Veratrole was demethylated to 2-methoxyphenol. From a Table presented in this Czech paper it is only possible to guess that the percentage of the administered dose that is metabolised to 2-methoxyphenol is between 6 and 22%.
Applicant's summary and conclusion
- Conclusions:
- Bioaccumulation potential cannot be judged based on study results
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