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EC number: 226-956-0 | CAS number: 5578-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There are no reliable aquatic toxicity data available for dichloro(cyclohexyl)methylsilane (CAS 5578-42-7), therefore good quality data for the structurally-related substance, cyclohexyl(dimethoxy)methylsilane (CAS 17865-32-6), have been read across.
Reliable short-term toxicity tests results are available for freshwater fish (Oncorhynchus mykiss), invertebrates (Daphnia magna) and algae (Desmodesmus subspicatus) for cyclohexyl(dimethoxy)methylsilane (CAS 17865-32-6). The relevant short-term values are:
Fish: LC50 (96 h): 50 mg/l based on nominal test substance concentrations. The LC50 value based on geometric mean measured concentrations of the parent substance is 35 mg/l. However, the fish were likely to have been exposed to a mixture of parent test substance and hydrolysis products. Because the relevant assessment entity is the silanol hydrolysis product cyclohexyl(methyl)silanediol, the nominal test substance concentration is used for chemical safety assessment with a molecular weight correction to reflect the concentration of cyclohexyl(methyl)silanediol. The relevant short-term toxicity to fish value, expressed in terms of concentration of the silanol hydrolysis product cyclohexyl(methyl)silanediol, is therefore 43 mg/l.
Daphnia: EC50 (48 h): 24 mg/l based on nominal test substance concentrations. The EC50 value based on geometric mean measured concentrations of the parent substance is 13 mg/l. However, the Daphnia were likely to have been exposed to a mixture of parent test substance and hydrolysis products, with the hydrolysis products predominating towards the end of the test. Because the relevant assessment entity is the silanol hydrolysis product cyclohexyl(methyl)silanediol, the nominal test substance concentration is used for chemical safety assessment with a molecular weight correction to reflect the concentration of cyclohexyl(methyl)silanediol. The relevant short-term toxicity to invertebrates value, expressed in terms of concentration of the silanol hydrolysis product cyclohexyl(methyl)silanediol, is therefore 20 mg/l.
Algae: EC50 (72 h): 35 mg/l; NOEC: 12.5 mg/l expressed in terms of nominal concentrations of test substance. However, exposure is likely to be a mixture of parent test substance and hydrolysis products, with the hydrolysis products predominating towards the end of the test. Because the relevant assessment entity is the silanol hydrolysis product cyclohexyl(methyl)silanediol, the nominal test substance concentration is used for chemical safety assessment with a molecular weight correction to reflect the concentration of cyclohexyl(methyl)silanediol. The relevant toxicity to algae values, expressed in terms of concentration of the silanol hydrolysis product cyclohexyl(methyl)silanediol, are therefore EC50 30 mg/l and NOEC 11 mg/l.
No toxicity to microorganisms data are available for dichloro(cyclohexyl)methylsilane. Data from an activated sludge respiration inhibition test for the structurally-related substance, dicyclopentyldichlorosilane (CAS 139147-73-2), have been read-across. An EC50value of >100mg/l was determined.
Data for the test substance dichloro(cyclohexyl)methylsilane (CAS 5578-42-7)
A 48-h EL50 value of 26 mg/l has been determined for the effects of the registered substance on mobility of Daphnia magna based on nominal test substance loading rate. The results of the study are considered to be uncertain due to the measured DOC (dissolved organic carbon) concentrations being 30% of nominal and this being attributable to the formation of insoluble polymers. The formation of polymers would not take place at the concentrations predicted in the environment (see Section 9 of the CSR) and the study is considered to be reliability 4 due to the uncertainty of the form of the substance the organisms were exposed to.
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