Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative Databases
Title:
Revised Robust Summaries and Test Plan for 1,2-dimethyl-4-nitrobenzene
Author:
U.S. Environmental Protection Agency
Year:
2009
Bibliographic source:
High Production Volume Challenge Program; Fisher, J., 1975, Toxicity data for o-xylene,4-nitro. Report No. A75-138, American Cyanamid Company, Agricultural Division, Princeton, NJ.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is taken from HPV Challenge Program.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitro-o-xylene
EC Number:
202-761-6
EC Name:
4-nitro-o-xylene
Cas Number:
99-51-4
Molecular formula:
C8H9NO2
IUPAC Name:
4-nitro-o-xylene

Test animals

Species:
rabbit

Test system

Type of coverage:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
other:
Remarks on result:
other: Not irritating

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The database indicates that 4-nitro-o-xylene is not irritating to skin of rabbits.
Executive summary:

The HPV database indicates that 4-nitro-o-xylene is not irritating to skin of rabbits.