Registration Dossier
Registration Dossier
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EC number: 412-000-1 | CAS number: 125051-32-3 CGI 784
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD method, GLP compliance
Data source
Reference
- Reference Type:
- other: inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD GUIDELINE No.471 (CORRESPONDING TO 84/449/EEC, B.13 AND B.14)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Bis(η5-cyclopentadienyl)-bis(2,6-difluoro-3-[pyrrol-1-yl]-phenyl)titanium
- EC Number:
- 412-000-1
- EC Name:
- Bis(η5-cyclopentadienyl)-bis(2,6-difluoro-3-[pyrrol-1-yl]-phenyl)titanium
- Cas Number:
- 125051-32-3
- Molecular formula:
- C30H22F4N2Ti
- IUPAC Name:
- titanium(4+) bis(2,6-difluoro-3-(1H-pyrrol-1-yl)benzen-1-ide) bis(cyclopenta-2,4-dien-1-ide)
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: SALMONELLA TYPHIMURIUM TA98, TA100, TA1535, TA1537; ESCHERICHIA COLI WP2uvrA
- Metabolic activation system:
- RAT LIVER MICROSOMAL FRACTION (S9 MIX)
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 312...5000 μg/plate
Concentration range in the main test (without metabolic activation): 312...5000 μg/plate - Vehicle / solvent:
- Solvent: ACETONE
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- other: not provided
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 μg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- other: not available
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 μg/plate)
- Additional information on results:
- Observations:
NO EVIDENCE OF INDUCTION OF POINT MUTATIONS IN PRESENCE OR ABSENCE OF METABOLIC ACTIVATION - Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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