Registration Dossier
Registration Dossier
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EC number: 412-000-1 | CAS number: 125051-32-3 CGI 784
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD method, GLP compliance
Data source
Reference
- Reference Type:
- other: inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD GUIDELINE No.402 (CORRESPONDING TO 84/449/EEC, B.3)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Bis(η5-cyclopentadienyl)-bis(2,6-difluoro-3-[pyrrol-1-yl]-phenyl)titanium
- EC Number:
- 412-000-1
- EC Name:
- Bis(η5-cyclopentadienyl)-bis(2,6-difluoro-3-[pyrrol-1-yl]-phenyl)titanium
- Cas Number:
- 125051-32-3
- Molecular formula:
- C30H22F4N2Ti
- IUPAC Name:
- titanium(4+) bis(2,6-difluoro-3-(1H-pyrrol-1-yl)benzen-1-ide) bis(cyclopenta-2,4-dien-1-ide)
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: OL. ARACHIDIS Ph.H.VI
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw ; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw ; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: COMMON SYMPTOS IN ACUTE TESTS (PILOERECTION, ABNORMAL BODY POSITION AND DYSPNEA) ALL ANIMALS RECOVERED WITHIN 4-5 DAYS
- Gross pathology:
- Effects on organs:
NONE - Other findings:
- Signs of toxicity (local):
NONE
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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